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dc.contributor.authorJohn, Gernot. T-
dc.contributor.authorMaschke, Rüdiger-
dc.description.abstractWhile sophisticated small-scale cultivation systems came to the market in the last few years, shake flasks maintain the economic alternative widely used in industry and academia. Yet, these vessels lack the sensors like turbidity, oxygen concentration and pH-values. Here we show how to overcome these hurdles. The first part covers measurement improvements for shake flasks with focus on back-scattered light for biomass growth monitoring and the utilization of sensor spots for a deeper insight into the “black box” shake flasks. We used plant cells as their growth often can’t be accurately monitored by simple offline OD measurements. The sensor spot measurements are further used to detect process events, enabling the prediction of metabolite depletion. In the second part, soft sensors based on engineering and biological characterizations of these vessels are introduced and explained, enabling researchers to predict process values and estimate growth curves.de_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc540: Chemiede_CH
dc.titleEnhanced process insights in shake flask cultivationsde_CH
dc.typeKonferenz: Sonstigesde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.conference.detailsBioTech 2019 : Biopharmaceutical Manufacturing and Single-Use Technologies, Wädenswil, 2-4 July 2019de_CH
zhaw.publication.reviewPeer review (Abstract)de_CH
Appears in collections:Publikationen Life Sciences und Facility Management

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