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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Inhibitory antibodies designed for matrix metalloproteinase modulation
Authors: Fischer, Thomas
Riedl, Rainer
et. al: No
DOI: 10.3390/molecules24122265
Published in: Molecules
Volume(Issue): 24
Issue: 12
Pages: 2265
Issue Date: 2019
Publisher / Ed. Institution: MDPI
ISSN: 1420-3049
Language: English
Subjects: Drug design; Inhibitory antibody; Matrix metalloproteinase; Selectivity; Tissue inhibitors of metalloproteinase; Amino acid sequence; Animal; Monoclonal antibody; Binding site; Human; Matrix metalloproteinase inhibitors; Molecular conformation; Molecular docking simulation; Molecular dynamics simulation; Protein binding; Structure-activity relationship
Subject (DDC): 571: Physiology and related subjects
Abstract: The family of matrix metalloproteinases (MMPs) consists of a set of biological targets that are involved in a multitude of severe pathogenic events such as different forms of cancers or arthritis. Modulation of the target class with small molecule drugs has not led to the anticipated success until present, as all clinical trials failed due to unacceptable side effects or a lack of therapeutic outcome. Monoclonal antibodies offer a tremendous therapeutic potential given their high target selectivity and good pharmacokinetic profiles. For the treatment of a variety of diseases there are already antibody therapies available and the number is increasing. Recently, several antibodies were developed for the selective inhibition of single MMPs that showed high potency and were therefore investigated in in vivo studies with promising results. In this review, we highlight the progress that has been achieved toward the design of inhibitory antibodies that successfully modulate MMP-9 and MMP-14.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Appears in collections:Publikationen Life Sciences und Facility Management

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