Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-19482
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dc.contributor.authorKosiol, Carolin-
dc.contributor.authorAnisimova, Maria-
dc.date.accessioned2020-02-19T14:16:48Z-
dc.date.available2020-02-19T14:16:48Z-
dc.date.issued2019-
dc.identifier.isbn978-1-4939-9073-3de_CH
dc.identifier.isbn978-1-4939-9074-0de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/19482-
dc.description.abstractPopulations evolve as mutations arise in individual organisms and, through hereditary transmission, may become "fixed" (shared by all individuals) in the population. Most mutations are lethal or have negative fitness consequences for the organism. Others have essentially no effect on organismal fitness and can become fixed through the neutral stochastic process known as random drift. However, mutations may also produce a selective advantage that boosts their chances of reaching fixation. Regions of genomes where new mutations are beneficial, rather than neutral or deleterious, tend to evolve more rapidly due to positive selection. Genes involved in immunity and defense are a well-known example; rapid evolution in these genes presumably occurs because new mutations help organisms to prevail in evolutionary "arms races" with pathogens. In recent years genome-wide scans for selection have enlarged our understanding of the genome evolution of various species. In this chapter, we will focus on methods to detect selection on the genome. In particular, we will discuss probabilistic models and how they have changed with the advent of new genome-wide data now available.de_CH
dc.language.isoende_CH
dc.publisherHumanade_CH
dc.relation.ispartofEvolutionary genomics : statistical and computational methodsde_CH
dc.relation.ispartofseriesMethods in Molecular Biologyde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectCodon modelde_CH
dc.subjectConserved and accelerated regionde_CH
dc.subjectPolymorphism-aware phylogenetic modelde_CH
dc.subjectPositive selection scande_CH
dc.subjectSelection-mutation modelde_CH
dc.subjectCodonde_CH
dc.subjectComputational Biologyde_CH
dc.subjectGenome-wide association studyde_CH
dc.subjectGenomicsde_CH
dc.subjectGenotypede_CH
dc.subjectMammalde_CH
dc.subjectGenetic modelsde_CH
dc.subjectStatistical modelde_CH
dc.subjectMutationde_CH
dc.subjectPhylogenyde_CH
dc.subjectGenetic polymorphismde_CH
dc.subjectSoftwarede_CH
dc.subjectMolecular evolutionde_CH
dc.subjectGenomede_CH
dc.subjectGenetic selectionde_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleSelection acting on genomesde_CH
dc.typeBuchbeitragde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
dc.identifier.doi10.1007/978-1-4939-9074-0_12de_CH
dc.identifier.doi10.21256/zhaw-19482-
dc.identifier.pmid31278671de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end397de_CH
zhaw.pages.start373de_CH
zhaw.parentwork.editorAnisimova, Maria-
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedComputational Genomicsde_CH
zhaw.author.additionalNode_CH
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Kosiol, C., & Anisimova, M. (2019). Selection acting on genomes. In M. Anisimova (Ed.), Evolutionary genomics : statistical and computational methods (pp. 373–397). Humana. https://doi.org/10.1007/978-1-4939-9074-0_12
Kosiol, C. and Anisimova, M. (2019) ‘Selection acting on genomes’, in M. Anisimova (ed.) Evolutionary genomics : statistical and computational methods. Humana, pp. 373–397. Available at: https://doi.org/10.1007/978-1-4939-9074-0_12.
C. Kosiol and M. Anisimova, “Selection acting on genomes,” in Evolutionary genomics : statistical and computational methods, M. Anisimova, Ed. Humana, 2019, pp. 373–397. doi: 10.1007/978-1-4939-9074-0_12.
KOSIOL, Carolin und Maria ANISIMOVA, 2019. Selection acting on genomes. In: Maria ANISIMOVA (Hrsg.), Evolutionary genomics : statistical and computational methods. Humana. S. 373–397. ISBN 978-1-4939-9073-3
Kosiol, Carolin, and Maria Anisimova. 2019. “Selection Acting on Genomes.” In Evolutionary Genomics : Statistical and Computational Methods, edited by Maria Anisimova, 373–97. Humana. https://doi.org/10.1007/978-1-4939-9074-0_12.
Kosiol, Carolin, and Maria Anisimova. “Selection Acting on Genomes.” Evolutionary Genomics : Statistical and Computational Methods, edited by Maria Anisimova, Humana, 2019, pp. 373–97, https://doi.org/10.1007/978-1-4939-9074-0_12.


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