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Publikationstyp: Buchbeitrag
Art der Begutachtung: Peer review (Publikation)
Titel: Selection acting on genomes
Autor/-in: Kosiol, Carolin
Anisimova, Maria
et. al: No
DOI: 10.1007/978-1-4939-9074-0_12
10.21256/zhaw-19482
Erschienen in: Evolutionary genomics : statistical and computational methods
Herausgeber/-in des übergeordneten Werkes: Anisimova, Maria
Seite(n): 373
Seiten bis: 397
Erscheinungsdatum: 2019
Reihe: Methods in Molecular Biology
Verlag / Hrsg. Institution: Humana
ISBN: 978-1-4939-9073-3
978-1-4939-9074-0
Sprache: Englisch
Schlagwörter: Codon model; Conserved and accelerated region; Polymorphism-aware phylogenetic model; Positive selection scan; Selection-mutation model; Codon; Computational Biology; Genome-wide association study; Genomics; Genotype; Mammal; Genetic models; Statistical model; Mutation; Phylogeny; Genetic polymorphism; Software; Molecular evolution; Genome; Genetic selection
Fachgebiet (DDC): 572: Biochemie
Zusammenfassung: Populations evolve as mutations arise in individual organisms and, through hereditary transmission, may become "fixed" (shared by all individuals) in the population. Most mutations are lethal or have negative fitness consequences for the organism. Others have essentially no effect on organismal fitness and can become fixed through the neutral stochastic process known as random drift. However, mutations may also produce a selective advantage that boosts their chances of reaching fixation. Regions of genomes where new mutations are beneficial, rather than neutral or deleterious, tend to evolve more rapidly due to positive selection. Genes involved in immunity and defense are a well-known example; rapid evolution in these genes presumably occurs because new mutations help organisms to prevail in evolutionary "arms races" with pathogens. In recent years genome-wide scans for selection have enlarged our understanding of the genome evolution of various species. In this chapter, we will focus on methods to detect selection on the genome. In particular, we will discuss probabilistic models and how they have changed with the advent of new genome-wide data now available.
URI: https://digitalcollection.zhaw.ch/handle/11475/19482
Volltext Version: Publizierte Version
Lizenz (gemäss Verlagsvertrag): CC BY 4.0: Namensnennung 4.0 International
Departement: Life Sciences und Facility Management
Organisationseinheit: Institut für Computational Life Sciences (ICLS)
Enthalten in den Sammlungen:Publikationen Life Sciences und Facility Management

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Kosiol, C., & Anisimova, M. (2019). Selection acting on genomes. In M. Anisimova (Ed.), Evolutionary genomics : statistical and computational methods (pp. 373–397). Humana. https://doi.org/10.1007/978-1-4939-9074-0_12
Kosiol, C. and Anisimova, M. (2019) ‘Selection acting on genomes’, in M. Anisimova (ed.) Evolutionary genomics : statistical and computational methods. Humana, pp. 373–397. Available at: https://doi.org/10.1007/978-1-4939-9074-0_12.
C. Kosiol and M. Anisimova, “Selection acting on genomes,” in Evolutionary genomics : statistical and computational methods, M. Anisimova, Ed. Humana, 2019, pp. 373–397. doi: 10.1007/978-1-4939-9074-0_12.
KOSIOL, Carolin und Maria ANISIMOVA, 2019. Selection acting on genomes. In: Maria ANISIMOVA (Hrsg.), Evolutionary genomics : statistical and computational methods. Humana. S. 373–397. ISBN 978-1-4939-9073-3
Kosiol, Carolin, and Maria Anisimova. 2019. “Selection Acting on Genomes.” In Evolutionary Genomics : Statistical and Computational Methods, edited by Maria Anisimova, 373–97. Humana. https://doi.org/10.1007/978-1-4939-9074-0_12.
Kosiol, Carolin, and Maria Anisimova. “Selection Acting on Genomes.” Evolutionary Genomics : Statistical and Computational Methods, edited by Maria Anisimova, Humana, 2019, pp. 373–97, https://doi.org/10.1007/978-1-4939-9074-0_12.


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