White matter regions with low microstructure in young adults spatially coincide with white matter hyperintensities in older adults

Lao, Patrick J.; Vorburger, Robert S.; Narkhede, Atul; Gazes, Yunglin; Igwe, Kay C.; Colón, Juliet; Amarante, Erica; Guzman, Vanessa A.; Last, Briana S.; Habeck, Christian; Stern, Yaakov; Brickman, Adam M.

doi:10.3389/fnagi.2019.00345

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-19129

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	White matter regions with low microstructure in young adults spatially coincide with white matter hyperintensities in older adults
Authors:	Lao, Patrick J. Vorburger, Robert S. Narkhede, Atul Gazes, Yunglin Igwe, Kay C. Colón, Juliet Amarante, Erica Guzman, Vanessa A. Last, Briana S. Habeck, Christian Stern, Yaakov Brickman, Adam M.
et. al:	No
DOI:	10.3389/fnagi.2019.00345 10.21256/zhaw-19129
Published in:	Frontiers in Aging Neuroscience
Volume(Issue):	11
Issue:	345
Issue Date:	10-Dec-2019
Publisher / Ed. Institution:	Frontiers Research Foundation
ISSN:	1663-4365
Language:	English
Subjects:	Magnetic resonance imaging; Aging; White matter hyperintensities
Subject (DDC):	610: Medicine and health
Abstract:	Microstructural and macrostructural white matter damage occurs frequently with aging, is associated with negative health outcomes, and can be imaged non-invasively as fractional anisotropy (FA) and white matter hyperintensities (WMH), respectively. The extent to which diminished microstructure precedes or results from macrostructural white matter damage is poorly understood. This study evaluated the hypothesis that white matter areas with normatively lower microstructure in young adults are most susceptible to develop WMH in older adults. Forty-nine younger participants (age = 25.8 ± 2.8 years) underwent diffusion-weighted imaging (DWI), and 557 older participants (age = 73.9 ± 5.7 years) underwent DWI and T2-weighted magnetic resonance imaging (MRI). In older adults, WMH had a mostly periventricular distribution with higher frequency in frontal regions. We found lower FA in areas of frank WMH compared to normal-appearing white matter (NAWM) in older adults. Then, to determine if areas of normatively lower white matter microstructure spatially overlap with areas that frequently develop macrostructural damage in older age, we created a WMH frequency map in which each voxel represented the percentage of older adults with a WMH in that voxel. We found lower normative FA in young adults with regions frequently segmented as WMH in older adults. We conclude that low white matter microstructure is observed in areas of white matter macrostructural damage, but white matter microstructure is also normatively low (i.e., at ages 20–30) in regions with high WMH frequency, prior to white matter macrostructural damage.
URI:	https://digitalcollection.zhaw.ch/handle/11475/19129
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	Life Sciences and Facility Management
Organisational Unit:	Institute of Computational Life Sciences (ICLS)
Appears in collections:	Publikationen Life Sciences und Facility Management

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Lao, P. J., Vorburger, R. S., Narkhede, A., Gazes, Y., Igwe, K. C., Colón, J., Amarante, E., Guzman, V. A., Last, B. S., Habeck, C., Stern, Y., & Brickman, A. M. (2019). White matter regions with low microstructure in young adults spatially coincide with white matter hyperintensities in older adults. Frontiers in Aging Neuroscience, 11(345). https://doi.org/10.3389/fnagi.2019.00345

Lao, P.J. et al. (2019) ‘White matter regions with low microstructure in young adults spatially coincide with white matter hyperintensities in older adults’, Frontiers in Aging Neuroscience, 11(345). Available at: https://doi.org/10.3389/fnagi.2019.00345.

P. J. Lao et al., “White matter regions with low microstructure in young adults spatially coincide with white matter hyperintensities in older adults,” Frontiers in Aging Neuroscience, vol. 11, no. 345, Dec. 2019, doi: 10.3389/fnagi.2019.00345.

LAO, Patrick J., Robert S. VORBURGER, Atul NARKHEDE, Yunglin GAZES, Kay C. IGWE, Juliet COLÓN, Erica AMARANTE, Vanessa A. GUZMAN, Briana S. LAST, Christian HABECK, Yaakov STERN und Adam M. BRICKMAN, 2019. White matter regions with low microstructure in young adults spatially coincide with white matter hyperintensities in older adults. Frontiers in Aging Neuroscience. 10 Dezember 2019. Bd. 11, Nr. 345. DOI 10.3389/fnagi.2019.00345

Lao, Patrick J., Robert S. Vorburger, Atul Narkhede, Yunglin Gazes, Kay C. Igwe, Juliet Colón, Erica Amarante, et al. 2019. “White Matter Regions with Low Microstructure in Young Adults Spatially Coincide with White Matter Hyperintensities in Older Adults.” Frontiers in Aging Neuroscience 11 (345). https://doi.org/10.3389/fnagi.2019.00345.

Lao, Patrick J., et al. “White Matter Regions with Low Microstructure in Young Adults Spatially Coincide with White Matter Hyperintensities in Older Adults.” Frontiers in Aging Neuroscience, vol. 11, no. 345, Dec. 2019, https://doi.org/10.3389/fnagi.2019.00345.