Please use this identifier to cite or link to this item:
Full metadata record
DC FieldValueLanguage
dc.contributor.authorLao, Patrick J.-
dc.contributor.authorVorburger, Robert S.-
dc.contributor.authorNarkhede, Atul-
dc.contributor.authorGazes, Yunglin-
dc.contributor.authorIgwe, Kay C.-
dc.contributor.authorColón, Juliet-
dc.contributor.authorAmarante, Erica-
dc.contributor.authorGuzman, Vanessa A.-
dc.contributor.authorLast, Briana S.-
dc.contributor.authorHabeck, Christian-
dc.contributor.authorStern, Yaakov-
dc.contributor.authorBrickman, Adam M.-
dc.description.abstractMicrostructural and macrostructural white matter damage occurs frequently with aging, is associated with negative health outcomes, and can be imaged non-invasively as fractional anisotropy (FA) and white matter hyperintensities (WMH), respectively. The extent to which diminished microstructure precedes or results from macrostructural white matter damage is poorly understood. This study evaluated the hypothesis that white matter areas with normatively lower microstructure in young adults are most susceptible to develop WMH in older adults. Forty-nine younger participants (age = 25.8 ± 2.8 years) underwent diffusion-weighted imaging (DWI), and 557 older participants (age = 73.9 ± 5.7 years) underwent DWI and T2-weighted magnetic resonance imaging (MRI). In older adults, WMH had a mostly periventricular distribution with higher frequency in frontal regions. We found lower FA in areas of frank WMH compared to normal-appearing white matter (NAWM) in older adults. Then, to determine if areas of normatively lower white matter microstructure spatially overlap with areas that frequently develop macrostructural damage in older age, we created a WMH frequency map in which each voxel represented the percentage of older adults with a WMH in that voxel. We found lower normative FA in young adults with regions frequently segmented as WMH in older adults. We conclude that low white matter microstructure is observed in areas of white matter macrostructural damage, but white matter microstructure is also normatively low (i.e., at ages 20–30) in regions with high WMH frequency, prior to white matter macrostructural damage.de_CH
dc.publisherFrontiers Research Foundationde_CH
dc.relation.ispartofFrontiers in Aging Neurosciencede_CH
dc.subjectMagnetic resonance imagingde_CH
dc.subjectWhite matter hyperintensitiesde_CH
dc.subject.ddc610: Medizin und Gesundheitde_CH
dc.titleWhite matter regions with low microstructure in young adults spatially coincide with white matter hyperintensities in older adultsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Computational Life Sciences (ICLS)de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedAngewandte Gerontologiede_CH
zhaw.webfeedData Management & Visualisationde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

Files in This Item:
File Description SizeFormat 
fnagi-11-00345.pdf3.91 MBAdobe PDFThumbnail

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.