Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-3342
Publication type: | Article in scientific journal |
Type of review: | Peer review (publication) |
Title: | Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort |
Authors: | Schikowski, Tamara Schaffner, Emmanuel Meier, Flurina Phuleria, Harish C. Vierkötter, Andrea Schindler, Christian Kriemler, Susi Zemp, Elisabeth Krämer, Ursula Bridevaux, Pierre-Olivier Rochat, Thierry Schwart, Joel Künzli, Nino Probst-Hensch, Nicole |
DOI: | 10.21256/zhaw-3342 10.1289/ehp.1206145 |
Published in: | Environmental Health Perspectives |
Volume(Issue): | 121 |
Issue: | 9 |
Page(s): | 1034 |
Pages to: | 1039 |
Issue Date: | 2013 |
Publisher / Ed. Institution: | National Institute of Environmental Health Sciences |
ISSN: | 0091-6765 1552-9924 |
Language: | English |
Subject (DDC): | 616: Internal medicine and diseases |
Abstract: | Background: Air pollution and obesity are hypothesized to contribute to accelerated decline in lung function with age through their inflammatory properties. Objective: We investigated whether the previously reported association between improved air quality and lung health in the population-based SAPALDIA cohort is modified by obesity. Methods: We used adjusted mixed-model analyses to estimate the association of average body mass index (BMI) and changes in particulate matter with aerodynamic diameter = 10 µm (PM10; ΔPM10) with lung function decline over a 10-year follow-up period. Results: Lung function data and complete information were available for 4,664 participants. Age-related declines in lung function among participants with high average BMI were more rapid for FVC (forced vital capacity), but slower for FEV1/FVC (forced expiratory volume in 1 sec/FVC) and FEF25-75 (forced expiratory flow at 25-75%) than declines among those with low or normal average BMI. Improved air quality was associated with attenuated reductions in FEV1/FVC, FEF25-75, and FEF25-75/FVC over time among low- and normal-BMI participants, but not overweight or obese participants. The attenuation was most pronounced for ΔFEF25-75/FVC (30% and 22% attenuation in association with a 10-µg/m3 decrease in PM10 among low- and normal-weight participants, respectively.) Conclusion: Our results point to the importance of considering health effects of air pollution exposure and obesity in parallel. Further research must address the mechanisms underlying the observed interaction. |
Further description: | All documents published by EHP are in the public domain. PDF copies of published articles can be freely shared and distributed without permission from either EHP or the authors. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/16419 |
Fulltext version: | Published version |
License (according to publishing contract): | Licence according to publishing contract |
Departement: | School of Management and Law |
Organisational Unit: | Winterthur Institute of Health Economics (WIG) |
Appears in collections: | Publikationen School of Management and Law |
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Improved Air Quality and Attenuated_SC 1.1_2013.pdf | 281.36 kB | Adobe PDF | View/Open |
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Schikowski, T., Schaffner, E., Meier, F., Phuleria, H. C., Vierkötter, A., Schindler, C., Kriemler, S., Zemp, E., Krämer, U., Bridevaux, P.-O., Rochat, T., Schwart, J., Künzli, N., & Probst-Hensch, N. (2013). Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort. Environmental Health Perspectives, 121(9), 1034–1039. https://doi.org/10.21256/zhaw-3342
Schikowski, T. et al. (2013) ‘Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort’, Environmental Health Perspectives, 121(9), pp. 1034–1039. Available at: https://doi.org/10.21256/zhaw-3342.
T. Schikowski et al., “Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort,” Environmental Health Perspectives, vol. 121, no. 9, pp. 1034–1039, 2013, doi: 10.21256/zhaw-3342.
SCHIKOWSKI, Tamara, Emmanuel SCHAFFNER, Flurina MEIER, Harish C. PHULERIA, Andrea VIERKÖTTER, Christian SCHINDLER, Susi KRIEMLER, Elisabeth ZEMP, Ursula KRÄMER, Pierre-Olivier BRIDEVAUX, Thierry ROCHAT, Joel SCHWART, Nino KÜNZLI und Nicole PROBST-HENSCH, 2013. Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort. Environmental Health Perspectives. 2013. Bd. 121, Nr. 9, S. 1034–1039. DOI 10.21256/zhaw-3342
Schikowski, Tamara, Emmanuel Schaffner, Flurina Meier, Harish C. Phuleria, Andrea Vierkötter, Christian Schindler, Susi Kriemler, et al. 2013. “Improved Air Quality and Attenuated Lung Function Decline : Modification by Obesity in the SAPALDIA Cohort.” Environmental Health Perspectives 121 (9): 1034–39. https://doi.org/10.21256/zhaw-3342.
Schikowski, Tamara, et al. “Improved Air Quality and Attenuated Lung Function Decline : Modification by Obesity in the SAPALDIA Cohort.” Environmental Health Perspectives, vol. 121, no. 9, 2013, pp. 1034–39, https://doi.org/10.21256/zhaw-3342.
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