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Title: Improved air quality and attenuated lung function decline : modification by obesity in the SAPALDIA cohort
Authors : Schikowski, Tamara
Schaffner, Emmanuel
Meier, Flurina
Phuleria, Harish C.
Vierkötter, Andrea
Schindler, Christian
Kriemler, Susi
Zemp, Elisabeth
Krämer, Ursula
Bridevaux, Pierre-Olivier
Rochat, Thierry
Schwart, Joel
Künzli, Nino
Probst-Hensch, Nicole
Published in : Environmental Health Perspectives
Volume(Issue) : 121
Issue : 9
Pages : 1034
Pages to: 1039
Publisher / Ed. Institution : National Institute of Environmental Health Sciences
Issue Date: 2013
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (publication)
Language : English
Subject (DDC) : 616: Internal medicine and diseases
Abstract: Background: Air pollution and obesity are hypothesized to contribute to accelerated decline in lung function with age through their inflammatory properties. Objective: We investigated whether the previously reported association between improved air quality and lung health in the population-based SAPALDIA cohort is modified by obesity. Methods: We used adjusted mixed-model analyses to estimate the association of average body mass index (BMI) and changes in particulate matter with aerodynamic diameter = 10 µm (PM10; ΔPM10) with lung function decline over a 10-year follow-up period. Results: Lung function data and complete information were available for 4,664 participants. Age-related declines in lung function among participants with high average BMI were more rapid for FVC (forced vital capacity), but slower for FEV1/FVC (forced expiratory volume in 1 sec/FVC) and FEF25-75 (forced expiratory flow at 25-75%) than declines among those with low or normal average BMI. Improved air quality was associated with attenuated reductions in FEV1/FVC, FEF25-75, and FEF25-75/FVC over time among low- and normal-BMI participants, but not overweight or obese participants. The attenuation was most pronounced for ΔFEF25-75/FVC (30% and 22% attenuation in association with a 10-µg/m3 decrease in PM10 among low- and normal-weight participants, respectively.) Conclusion: Our results point to the importance of considering health effects of air pollution exposure and obesity in parallel. Further research must address the mechanisms underlying the observed interaction.
Further description : All documents published by EHP are in the public domain. PDF copies of published articles can be freely shared and distributed without permission from either EHP or the authors.
Departement: School of Management and Law
Organisational Unit: Winterthur Institute of Health Economics (WIG)
Publication type: Article in scientific journal
DOI : 10.21256/zhaw-3342
ISSN: 0091-6765
Appears in Collections:Publikationen School of Management and Law

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