Title: Simulated moving bed chromatography : the next step in HPLC
Authors : van Oordt, Thomas
Bayliss, Edwin
Netscher, Thomas
Bonrath, Werner
Spielmann, Thomas
Published in : Chimia
Volume(Issue) : 60
Issue : 3
Pages : 150
Pages to: 152
Publisher / Ed. Institution : Schweizerische Chemische Gesellschaft
Issue Date: 2006
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Preparative Chromatography; Simulated Moving Bed; Tocopherols; Tocotrienols; Vitamin E
Subject (DDC) : 660: Chemical engineering
Abstract: Simulated Moving Bed (SMB) technology, a continuous chromatographic separation process, is of increasing interest in the field of pharmaceuticals, fine chemicals, and biotechnology. The complexity of SMB asks for a deeper understanding of the mathematical design and physical adsorption processes, along with the practical training in chromatography and process engineering. This makes SMB a technology which is also suitable for educational purposes. The principle of SMB separation is described with a short introduction of its mathematical design for a simulation. A method of measuring the adsorption isotherms, which are crucial for a process simulation, is also discussed. As an example, the application of SMB to the separation of two groups of biologically important vitamin E compounds, i.e. tocopherols and tocotrienols from natural-source material is presented.
Departement: School of Engineering
Organisational Unit: Institute of Materials and Process Engineering (IMPE)
Publication type: Article in scientific Journal
DOI : 10.2533/000942906777674967
ISSN: 0009-4293
URI: https://digitalcollection.zhaw.ch/handle/11475/16232
Appears in Collections:Publikationen School of Engineering

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