|Title:||Simulated moving bed chromatography : the next step in HPLC|
|Authors :||van Oordt, Thomas|
|Published in :||Chimia|
|Publisher / Ed. Institution :||Schweizerische Chemische Gesellschaft|
|License (according to publishing contract) :||Licence according to publishing contract|
|Type of review:||Peer review (Publication)|
|Subjects :||Preparative Chromatography; Simulated Moving Bed; Tocopherols; Tocotrienols; Vitamin E|
|Subject (DDC) :||660: Chemical engineering|
|Abstract:||Simulated Moving Bed (SMB) technology, a continuous chromatographic separation process, is of increasing interest in the field of pharmaceuticals, fine chemicals, and biotechnology. The complexity of SMB asks for a deeper understanding of the mathematical design and physical adsorption processes, along with the practical training in chromatography and process engineering. This makes SMB a technology which is also suitable for educational purposes. The principle of SMB separation is described with a short introduction of its mathematical design for a simulation. A method of measuring the adsorption isotherms, which are crucial for a process simulation, is also discussed. As an example, the application of SMB to the separation of two groups of biologically important vitamin E compounds, i.e. tocopherols and tocotrienols from natural-source material is presented.|
|Departement:||School of Engineering|
|Organisational Unit:||Institute of Materials and Process Engineering (IMPE)|
|Publication type:||Article in scientific Journal|
|Appears in Collections:||Publikationen School of Engineering|
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