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Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance
Authors: Dengler Haunreiter, Vanina
Boumasmoud, Mathilde
Häffner, Nicola
Wipfli, Dennis
Leimer, Nadja
Rachmühl, Carole
Kühnert, Denise
Achermann, Yvonne
Zbinden, Reinhard
Benussi, Stefano
Vulin, Clement
Zinkernagel, Annelies S.
DOI: 10.21256/zhaw-5506
Published in: Nature Communications
Volume(Issue): 10
Issue: 1149
Issue Date: 2019
Publisher / Ed. Institution: Nature
ISSN: 2041-1723
Language: English
Subject (DDC): 570: Biology
615: Pharmacology and therapeutics
Abstract: Treatment failure in biofilm-associated bacterial infections is an important healthcare issue. In vitro studies and mouse models suggest that bacteria enter a slow-growing/non-growing state that results in transient tolerance to antibiotics in the absence of a specific resistance mechanism. However, little clinical confirmation of antibiotic tolerant bacteria in patients exists. In this study we investigate a Staphylococcus epidermidis pacemaker-associated endocarditis, in a patient who developed a break-through bacteremia despite taking antibiotics to which the S. epidermidis isolate is fully susceptible in vitro. Characterization of the clinical S. epidermidis isolates reveals in-host evolution over the 16-week infection period, resulting in increased antibiotic tolerance of the entire population due to a prolonged lag time until growth resumption and a reduced growth rate. Furthermore, we observe adaptation towards an increased biofilm formation capacity and genetic diversification of the S. epidermidis isolates within the patient.
Fulltext version: Published version
License (according to publishing contract): CC BY 4.0: Attribution 4.0 International
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in Collections:Publikationen Life Sciences und Facility Management

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