Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-5506
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dc.contributor.authorDengler Haunreiter, Vanina-
dc.contributor.authorBoumasmoud, Mathilde-
dc.contributor.authorHäffner, Nicola-
dc.contributor.authorWipfli, Dennis-
dc.contributor.authorLeimer, Nadja-
dc.contributor.authorRachmühl, Carole-
dc.contributor.authorKühnert, Denise-
dc.contributor.authorAchermann, Yvonne-
dc.contributor.authorZbinden, Reinhard-
dc.contributor.authorBenussi, Stefano-
dc.contributor.authorVulin, Clement-
dc.contributor.authorZinkernagel, Annelies S.-
dc.date.accessioned2019-03-15T13:53:00Z-
dc.date.available2019-03-15T13:53:00Z-
dc.date.issued2019-
dc.identifier.issn2041-1723de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/16117-
dc.description.abstractTreatment failure in biofilm-associated bacterial infections is an important healthcare issue. In vitro studies and mouse models suggest that bacteria enter a slow-growing/non-growing state that results in transient tolerance to antibiotics in the absence of a specific resistance mechanism. However, little clinical confirmation of antibiotic tolerant bacteria in patients exists. In this study we investigate a Staphylococcus epidermidis pacemaker-associated endocarditis, in a patient who developed a break-through bacteremia despite taking antibiotics to which the S. epidermidis isolate is fully susceptible in vitro. Characterization of the clinical S. epidermidis isolates reveals in-host evolution over the 16-week infection period, resulting in increased antibiotic tolerance of the entire population due to a prolonged lag time until growth resumption and a reduced growth rate. Furthermore, we observe adaptation towards an increased biofilm formation capacity and genetic diversification of the S. epidermidis isolates within the patient.de_CH
dc.language.isoende_CH
dc.publisherNaturede_CH
dc.relation.ispartofNature Communicationsde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subject.ddc570: Biologiede_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleIn-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerancede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.21256/zhaw-5506-
dc.identifier.doi10.1038/s41467-019-09053-9de_CH
dc.identifier.pmid30850614de_CH
zhaw.funding.euNode_CH
zhaw.issue1149de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume10de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedMikrobiologiede_CH
Appears in Collections:Publikationen Life Sciences und Facility Management

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