Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-5506
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Dengler Haunreiter, Vanina | - |
dc.contributor.author | Boumasmoud, Mathilde | - |
dc.contributor.author | Häffner, Nicola | - |
dc.contributor.author | Wipfli, Dennis | - |
dc.contributor.author | Leimer, Nadja | - |
dc.contributor.author | Rachmühl, Carole | - |
dc.contributor.author | Kühnert, Denise | - |
dc.contributor.author | Achermann, Yvonne | - |
dc.contributor.author | Zbinden, Reinhard | - |
dc.contributor.author | Benussi, Stefano | - |
dc.contributor.author | Vulin, Clement | - |
dc.contributor.author | Zinkernagel, Annelies S. | - |
dc.date.accessioned | 2019-03-15T13:53:00Z | - |
dc.date.available | 2019-03-15T13:53:00Z | - |
dc.date.issued | 2019 | - |
dc.identifier.issn | 2041-1723 | de_CH |
dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/16117 | - |
dc.description.abstract | Treatment failure in biofilm-associated bacterial infections is an important healthcare issue. In vitro studies and mouse models suggest that bacteria enter a slow-growing/non-growing state that results in transient tolerance to antibiotics in the absence of a specific resistance mechanism. However, little clinical confirmation of antibiotic tolerant bacteria in patients exists. In this study we investigate a Staphylococcus epidermidis pacemaker-associated endocarditis, in a patient who developed a break-through bacteremia despite taking antibiotics to which the S. epidermidis isolate is fully susceptible in vitro. Characterization of the clinical S. epidermidis isolates reveals in-host evolution over the 16-week infection period, resulting in increased antibiotic tolerance of the entire population due to a prolonged lag time until growth resumption and a reduced growth rate. Furthermore, we observe adaptation towards an increased biofilm formation capacity and genetic diversification of the S. epidermidis isolates within the patient. | de_CH |
dc.language.iso | en | de_CH |
dc.publisher | Nature Publishing Group | de_CH |
dc.relation.ispartof | Nature Communications | de_CH |
dc.rights | http://creativecommons.org/licenses/by/4.0/ | de_CH |
dc.subject.ddc | 570: Biologie | de_CH |
dc.subject.ddc | 615: Pharmakologie und Therapeutik | de_CH |
dc.title | In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance | de_CH |
dc.type | Beitrag in wissenschaftlicher Zeitschrift | de_CH |
dcterms.type | Text | de_CH |
zhaw.departement | Life Sciences und Facility Management | de_CH |
zhaw.organisationalunit | Institut für Chemie und Biotechnologie (ICBT) | de_CH |
dc.identifier.doi | 10.1038/s41467-019-09053-9 | de_CH |
dc.identifier.doi | 10.21256/zhaw-5506 | - |
dc.identifier.pmid | 30850614 | de_CH |
zhaw.funding.eu | No | de_CH |
zhaw.issue | 1149 | de_CH |
zhaw.originated.zhaw | Yes | de_CH |
zhaw.publication.status | publishedVersion | de_CH |
zhaw.volume | 10 | de_CH |
zhaw.publication.review | Peer review (Publikation) | de_CH |
zhaw.webfeed | Mikrobiologie | de_CH |
Appears in collections: | Publikationen Life Sciences und Facility Management |
Files in This Item:
File | Description | Size | Format | |
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2019_In-host_evolution_of_Staphylococcus_epidermidis_NatureCommunications.pdf | 3.19 MB | Adobe PDF | View/Open |
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Dengler Haunreiter, V., Boumasmoud, M., Häffner, N., Wipfli, D., Leimer, N., Rachmühl, C., Kühnert, D., Achermann, Y., Zbinden, R., Benussi, S., Vulin, C., & Zinkernagel, A. S. (2019). In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance. Nature Communications, 10(1149). https://doi.org/10.1038/s41467-019-09053-9
Dengler Haunreiter, V. et al. (2019) ‘In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance’, Nature Communications, 10(1149). Available at: https://doi.org/10.1038/s41467-019-09053-9.
V. Dengler Haunreiter et al., “In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance,” Nature Communications, vol. 10, no. 1149, 2019, doi: 10.1038/s41467-019-09053-9.
DENGLER HAUNREITER, Vanina, Mathilde BOUMASMOUD, Nicola HÄFFNER, Dennis WIPFLI, Nadja LEIMER, Carole RACHMÜHL, Denise KÜHNERT, Yvonne ACHERMANN, Reinhard ZBINDEN, Stefano BENUSSI, Clement VULIN und Annelies S. ZINKERNAGEL, 2019. In-host evolution of Staphylococcus epidermidis in a pacemaker-associated endocarditis resulting in increased antibiotic tolerance. Nature Communications. 2019. Bd. 10, Nr. 1149. DOI 10.1038/s41467-019-09053-9
Dengler Haunreiter, Vanina, Mathilde Boumasmoud, Nicola Häffner, Dennis Wipfli, Nadja Leimer, Carole Rachmühl, Denise Kühnert, et al. 2019. “In-Host Evolution of Staphylococcus Epidermidis in a Pacemaker-Associated Endocarditis Resulting in Increased Antibiotic Tolerance.” Nature Communications 10 (1149). https://doi.org/10.1038/s41467-019-09053-9.
Dengler Haunreiter, Vanina, et al. “In-Host Evolution of Staphylococcus Epidermidis in a Pacemaker-Associated Endocarditis Resulting in Increased Antibiotic Tolerance.” Nature Communications, vol. 10, no. 1149, 2019, https://doi.org/10.1038/s41467-019-09053-9.
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