Title: Synthetic 3D multicellular systems for drug development
Authors : Rimann, Markus
Graf-Hausner, Ursula
Published in : Current Opinion in Biotechnology
Volume(Issue) : 23
Issue : 5
Pages : 803
Pages to: 809
Publisher / Ed. Institution : Elsevier
Issue Date: 2012
Language : Englisch / English
Subject (DDC) : 615: Pharmakologie und Therapeutik
660.6: Biotechnologie
Abstract: Since the 1970s, the limitations of two dimensional (2D) cell culture and the relevance of appropriate three dimensional (3D) cell systems have become increasingly evident. Extensive effort has thus been made to move cells from a flat world to a 3D environment. While 3D cell culture technologies are meanwhile widely used in academia, 2D culture technologies are still entrenched in the (pharmaceutical) industry for most kind of cell-based efficacy and toxicology tests. However, 3D cell culture technologies will certainly become more applicable if biological relevance, reproducibility and high throughput can be assured at acceptable costs. Most recent innovations and developments clearly indicate that the transition from 2D to 3D cell culture for industrial purposes, for example, drug development is simply a question of time.
Departement: Life Sciences und Facility Management
Publication type: Beitrag in wissenschaftlicher Zeitschrift / Article in scientific Journal
DOI : 10.1016/j.copbio.2012.01.011
ISSN: 0958-1669
URI: https://digitalcollection.zhaw.ch/handle/11475/1604
Appears in Collections:Publikationen Life Sciences und Facility Management

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