Title: Prolonged cytotoxic effect of aqueous extracts from dired Viscum album on bladder cancer cells
Authors : Hunziker-Basler, N.
Zuzak, T.
Eggenschwiler, Jenny
Rist, L.
Simoes-Wüst, A.P.
Viviani, A.
Published in : Die Pharmazie
Volume(Issue) : 62
Issue : 3
Pages : 237
Pages to: 238
Publisher / Ed. Institution : Avoxa
Issue Date: 2007
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subject (DDC) : 615: Pharmacology and therapeutics
Abstract: Aqueous extracts from whole dried mistletoe (Viscum album L., Iscucin®) are often used in anti-cancer treatment. We studied the effect of extracts obtained from mistletoe bushes that grew on different host trees on bladder cancer cells by means of MTT-colorimetric cell proliferation/survival assays. The extracts possessed concentration-dependent cytotoxic properties whose extent varied with the host tree, but did not always correlate with the corresponding mistletoe lectin content. A 2-hours treatment of bladder cancer cells triggered a later, strong cytotoxic effect. This prolonged effect suggests that instillation with Iscucin® has therapeutic potential for bladder cancer patients.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
ISSN: 0031-7144
URI: https://digitalcollection.zhaw.ch/handle/11475/15280
Appears in Collections:Publikationen Life Sciences und Facility Management

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