Publication type: | Article in scientific journal |
Type of review: | Peer review (publication) |
Title: | In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces |
Authors: | Weidenbacher, Lukas Müller, Eike Guex, Anne Géraldine Zündel, Manuel Schweizer, Peter Marina, Vita Adlhart, Christian Vejsadová, Lucie Pauer, Robin Spiecker, Erdmann Maniura-Weber, Katharina Ferguson, Stephen J. Rossi, René M. Rottmar, Markus Fortunato, Giuseppino |
DOI: | 10.1021/acsami.8b18121 |
Published in: | ACS Applied Materials & Interfaces |
Issue Date: | 2019 |
Publisher / Ed. Institution: | American Chemical Society |
ISSN: | 1944-8244 1944-8252 |
Language: | English |
Subjects: | Electrospun composite materials; Endothelialization; Fluorinated surface functionalization; Pulsatile flow bioreactor; Thrombogenicity |
Subject (DDC): | 660: Chemical engineering |
Abstract: | Despite major technological advances within the field of cardiovascular engineering, the risk of thromboembolic events on artificial surfaces in contact with blood remains a major challenge and limits the functionality of ventricular assist devices (VADs) during mid- or long-term therapy. Here, a biomimetic blood–material interface is created via a nanofiber-based approach that promotes the endothelialization capability of elastic silicone surfaces for next-generation VADs under elevated hemodynamic loads. A blend fiber membrane made of elastic polyurethane and low-thrombogenic poly(vinylidene fluoride-co-hexafluoropropylene) was partially embedded into the surface of silicone films. These blend membranes resist fundamental irreversible deformation of the internal structure and are stably attached to the surface, while also exhibiting enhanced antithrombotic properties when compared to bare silicone. The composite material supports the formation of a stable monolayer of endothelial cells within a pulsatile flow bioreactor, resembling the physiological in vivo situation in a VAD. The nanofiber surface modification concept thus presents a promising approach for the future design of advanced elastic composite materials that are particularly interesting for applications in contact with blood. |
URI: | https://digitalcollection.zhaw.ch/handle/11475/15177 |
Fulltext version: | Published version |
License (according to publishing contract): | Licence according to publishing contract |
Departement: | Life Sciences and Facility Management |
Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
Appears in collections: | Publikationen Life Sciences und Facility Management |
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Weidenbacher, L., Müller, E., Guex, A. G., Zündel, M., Schweizer, P., Marina, V., Adlhart, C., Vejsadová, L., Pauer, R., Spiecker, E., Maniura-Weber, K., Ferguson, S. J., Rossi, R. M., Rottmar, M., & Fortunato, G. (2019). In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces. ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.8b18121
Weidenbacher, L. et al. (2019) ‘In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces’, ACS Applied Materials & Interfaces [Preprint]. Available at: https://doi.org/10.1021/acsami.8b18121.
L. Weidenbacher et al., “In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces,” ACS Applied Materials & Interfaces, 2019, doi: 10.1021/acsami.8b18121.
WEIDENBACHER, Lukas, Eike MÜLLER, Anne Géraldine GUEX, Manuel ZÜNDEL, Peter SCHWEIZER, Vita MARINA, Christian ADLHART, Lucie VEJSADOVÁ, Robin PAUER, Erdmann SPIECKER, Katharina MANIURA-WEBER, Stephen J. FERGUSON, René M. ROSSI, Markus ROTTMAR und Giuseppino FORTUNATO, 2019. In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces. ACS Applied Materials & Interfaces. 2019. DOI 10.1021/acsami.8b18121
Weidenbacher, Lukas, Eike Müller, Anne Géraldine Guex, Manuel Zündel, Peter Schweizer, Vita Marina, Christian Adlhart, et al. 2019. “In Vitro Endothelialization of Surface-Integrated Nanofiber Networks for Stretchable Blood Interfaces.” ACS Applied Materials & Interfaces. https://doi.org/10.1021/acsami.8b18121.
Weidenbacher, Lukas, et al. “In Vitro Endothelialization of Surface-Integrated Nanofiber Networks for Stretchable Blood Interfaces.” ACS Applied Materials & Interfaces, 2019, https://doi.org/10.1021/acsami.8b18121.
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