Title: In vitro endothelialization of surface-integrated nanofiber networks for stretchable blood interfaces
Authors : Weidenbacher, Lukas
Müller, Eike
Guex, Anne Géraldine
Zündel, Manuel
Schweizer, Peter
Marina, Vita
Adlhart, Christian
Vejsadová, Lucie
Pauer, Robin
Spiecker, Erdmann
Maniura-Weber, Katharina
Ferguson, Stephen J.
Rossi, René M.
Rottmar, Markus
Fortunato, Giuseppino
Published in : ACS Applied Materials & Interfaces
Publisher / Ed. Institution : American Chemical Society
Issue Date: 2019
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Electrospun composite materials; Endothelialization; Fluorinated surface functionalization; Pulsatile flow bioreactor; Thrombogenicity
Subject (DDC) : 660: Chemical engineering
Abstract: Despite major technological advances within the field of cardiovascular engineering, the risk of thromboembolic events on artificial surfaces in contact with blood remains a major challenge and limits the functionality of ventricular assist devices (VADs) during mid- or long-term therapy. Here, a biomimetic blood–material interface is created via a nanofiber-based approach that promotes the endothelialization capability of elastic silicone surfaces for next-generation VADs under elevated hemodynamic loads. A blend fiber membrane made of elastic polyurethane and low-thrombogenic poly(vinylidene fluoride-co-hexafluoropropylene) was partially embedded into the surface of silicone films. These blend membranes resist fundamental irreversible deformation of the internal structure and are stably attached to the surface, while also exhibiting enhanced antithrombotic properties when compared to bare silicone. The composite material supports the formation of a stable monolayer of endothelial cells within a pulsatile flow bioreactor, resembling the physiological in vivo situation in a VAD. The nanofiber surface modification concept thus presents a promising approach for the future design of advanced elastic composite materials that are particularly interesting for applications in contact with blood.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific Journal
DOI : 10.1021/acsami.8b18121
ISSN: 1944-8244
1944-8252
URI: https://digitalcollection.zhaw.ch/handle/11475/15177
Appears in Collections:Publikationen Life Sciences und Facility Management

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