Title: Dynamic DNA damage and repair modeling : bridging the gap between experimental damage readout and model structure
Authors : Weyland, Mathias
Thumser-Henner, Pauline
Rohrer Bley, Carla
Ulzega, Simone
Petri-Fink, Alke
Lattuada, Marco
Scheidegger, Stephan
Füchslin, Rudolf Marcel
Conference details: WIVACE 2018, XIII Workshop on Artificial Life and Evolutionary Computation, Parma, Italy, 10-12 September 2018
Issue Date: 2018
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (abstract)
Language : English
Subject (DDC) : 572: Biochemistry
Abstract: In this work, a method is presented to map a set of experimentally obtained, time-resolved distributions to a dynamic model. Specifically, time-resolved comet assay readouts of cancer cells after application of ionizing radiation are mapped to the Multi-Hit-Repair model, a radiobiologically motivated dynamic model used to predict DNA dam- age and repair. Differential evolution is used for parameter-search to showcase the potential of this method, producing a prediction close to the experimental measurement. The results obtained from the parameter search are used to characterize aspects of the repair process. The method is compared to prior attempts of finding model parameters from dose-response curves, revealing that calibration is required to render the two comparable.
Further description : Oral presentation
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Applied Simulation (IAS)
Publication type: Conference other
URI: https://digitalcollection.zhaw.ch/handle/11475/14623
Published as part of the ZHAW project : Phantom- and Model-based Optimisation of Medical Imaging Modalities
Appears in Collections:Publikationen Life Sciences und Facility Management

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