Title: Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression
Authors : Skrundz, Marta
Bolten, Margarete
Nast, Irina
Hellhammer, Dirk H.
Meinlschmidt, Gunther
Published in : Neuropsychopharmacology
Volume(Issue) : 36
Issue : 9
Pages : 1886
Pages to: 1893
Publisher / Ed. Institution : Springer
Issue Date: Aug-2011
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (Publication)
Language : English
Subjects : Adult; Biomarkers; Depression, Postpartum; Female; Humans; Infant, Newborn; Longitudinal Studies; Male; Oxytocin; Predictive Value of Tests; Pregnancy; Pregnancy Complications; Pregnancy Trimester, Third; Prospective Studies; Risk Factors
Subject (DDC) : 615: Pharmacology and therapeutics
618: Gynecology, obstetrics and midwifery
Abstract: Postpartum depression (PPD) affects up to 19% of all women after parturition. The non-apeptide oxytocin (OXT) is involved in adjustment to pregnancy, maternal behavior, and bonding. Our aim was to examine the possible association between plasma OXT during pregnancy and the development of PPD symptoms. A total of 74 healthy, pregnant women were included in this prospective study. During the third trimester of pregnancy and within 2 weeks after parturition, PPD symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Blood samples for plasma OXT assessment were collected in the third trimester. Following the literature, participants with postpartum EPDS scores of 10 or more were regarded as being at risk for PPD development (rPPD group). In a logistic regression analysis, plasma OXT was included as a potential predictor for being at risk for PPD. Results were controlled for prepartal EPDS score, sociodemographic and birth-outcome variables. Plasma OXT concentration in mid-pregnancy significantly predicted PPD symptoms at 2 weeks postpartum. Compared with the no-risk-for-PPD group, the rPPD group was characterized by lower plasma OXT concentrations. To our knowledge, this is the first study to show an association between prepartal plasma OXT concentration and postpartal symptoms of PPD in humans. Assuming a causal relationship, enhancing OXT release during pregnancy could serve as a potential target in prepartum PPD prevention, and help to minimize adverse effects of PPD on the mother-child relationship.
Departement: Health Professions
Organisational Unit: Institute of Physiotherapy (IPT)
Publication type: Article in scientific Journal
DOI : 10.1038/npp.2011.74
ISSN: 1740-634X
URI: https://digitalcollection.zhaw.ch/handle/11475/14573
Appears in Collections:Publikationen Gesundheit

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