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dc.contributor.authorSkrundz, Marta-
dc.contributor.authorBolten, Margarete-
dc.contributor.authorNast, Irina-
dc.contributor.authorHellhammer, Dirk H.-
dc.contributor.authorMeinlschmidt, Gunther-
dc.date.accessioned2019-01-23T15:31:09Z-
dc.date.available2019-01-23T15:31:09Z-
dc.date.issued2011-08-
dc.identifier.issn1740-634Xde_CH
dc.identifier.issn0893-133Xde_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/14573-
dc.description.abstractPostpartum depression (PPD) affects up to 19% of all women after parturition. The non-apeptide oxytocin (OXT) is involved in adjustment to pregnancy, maternal behavior, and bonding. Our aim was to examine the possible association between plasma OXT during pregnancy and the development of PPD symptoms. A total of 74 healthy, pregnant women were included in this prospective study. During the third trimester of pregnancy and within 2 weeks after parturition, PPD symptoms were assessed using the Edinburgh Postnatal Depression Scale (EPDS). Blood samples for plasma OXT assessment were collected in the third trimester. Following the literature, participants with postpartum EPDS scores of 10 or more were regarded as being at risk for PPD development (rPPD group). In a logistic regression analysis, plasma OXT was included as a potential predictor for being at risk for PPD. Results were controlled for prepartal EPDS score, sociodemographic and birth-outcome variables. Plasma OXT concentration in mid-pregnancy significantly predicted PPD symptoms at 2 weeks postpartum. Compared with the no-risk-for-PPD group, the rPPD group was characterized by lower plasma OXT concentrations. To our knowledge, this is the first study to show an association between prepartal plasma OXT concentration and postpartal symptoms of PPD in humans. Assuming a causal relationship, enhancing OXT release during pregnancy could serve as a potential target in prepartum PPD prevention, and help to minimize adverse effects of PPD on the mother-child relationship.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofNeuropsychopharmacologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectAdultde_CH
dc.subjectBiomarkersde_CH
dc.subjectDepression, Postpartumde_CH
dc.subjectFemalede_CH
dc.subjectHumansde_CH
dc.subjectInfant, Newbornde_CH
dc.subjectLongitudinal Studiesde_CH
dc.subjectMalede_CH
dc.subjectOxytocinde_CH
dc.subjectPredictive Value of Testsde_CH
dc.subjectPregnancyde_CH
dc.subjectPregnancy Complicationsde_CH
dc.subjectPregnancy Trimester, Thirdde_CH
dc.subjectProspective Studiesde_CH
dc.subjectRisk Factorsde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.subject.ddc618: Geburtsmedizin und Hebammenarbeitde_CH
dc.titlePlasma oxytocin concentration during pregnancy is associated with development of postpartum depressionde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Physiotherapie (IPT)de_CH
dc.identifier.doi10.1038/npp.2011.74de_CH
dc.identifier.pmid21562482de_CH
zhaw.funding.euNode_CH
zhaw.issue9de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end1893de_CH
zhaw.pages.start1886de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume36de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Skrundz, M., Bolten, M., Nast, I., Hellhammer, D. H., & Meinlschmidt, G. (2011). Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression. Neuropsychopharmacology, 36(9), 1886–1893. https://doi.org/10.1038/npp.2011.74
Skrundz, M. et al. (2011) ‘Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression’, Neuropsychopharmacology, 36(9), pp. 1886–1893. Available at: https://doi.org/10.1038/npp.2011.74.
M. Skrundz, M. Bolten, I. Nast, D. H. Hellhammer, and G. Meinlschmidt, “Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression,” Neuropsychopharmacology, vol. 36, no. 9, pp. 1886–1893, Aug. 2011, doi: 10.1038/npp.2011.74.
SKRUNDZ, Marta, Margarete BOLTEN, Irina NAST, Dirk H. HELLHAMMER und Gunther MEINLSCHMIDT, 2011. Plasma oxytocin concentration during pregnancy is associated with development of postpartum depression. Neuropsychopharmacology. August 2011. Bd. 36, Nr. 9, S. 1886–1893. DOI 10.1038/npp.2011.74
Skrundz, Marta, Margarete Bolten, Irina Nast, Dirk H. Hellhammer, and Gunther Meinlschmidt. 2011. “Plasma Oxytocin Concentration during Pregnancy Is Associated with Development of Postpartum Depression.” Neuropsychopharmacology 36 (9): 1886–93. https://doi.org/10.1038/npp.2011.74.
Skrundz, Marta, et al. “Plasma Oxytocin Concentration during Pregnancy Is Associated with Development of Postpartum Depression.” Neuropsychopharmacology, vol. 36, no. 9, Aug. 2011, pp. 1886–93, https://doi.org/10.1038/npp.2011.74.


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