Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-14456
Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: A three-generation study on the association of tobacco smoking with asthma
Authors: Accordini, Simone
Calciano, Lucia
Johannessen, Ane
Portas, Laura
Benediktsdóttir, Bryndis
Bertelsen, Randi Jacobsen
Bråbäck, Lennart
Carsin, Anne-Elie
Dharmage, Shyamali C
Dratva, Julia
Forsberg, Bertil
Gomez Real, Francisco
Heinrich, Joachim
Holloway, John W
Holm, Mathias
Janson, Christer
Jögi, Rain
Leynaert, Bénédicte
Malinovschi, Andrei
Marcon, Alessandro
Martínez-Moratalla Rovira, Jesús
Raherison, Chantal
Sánchez-Ramos, José Luis
Schlünssen, Vivi
Bono, Roberto
Corsico, Angelo G
Demoly, Pascal
Dorado Arenas, Sandra
Nowak, Dennis
Pin, Isabelle
Weyler, Joost
Jarvis, Deborah
Svanes, Cecilie
DOI: 10.1093/ije/dyy031
10.21256/zhaw-14456
Published in: International Journal of Epidemiology
Volume(Issue): 47
Issue: 4
Page(s): 1106
Pages to: 1117
Issue Date: 2018
Publisher / Ed. Institution: Oxford University Press
ISSN: 0300-5771
1464-3685
Language: English
Subject (DDC): 616: Internal medicine and diseases
Abstract: Background: Mothers’ smoking during pregnancy increases asthma risk in their offspring. There is some evidence that grandmothers’ smoking may have a similar effect, and biological plausibility that fathers’ smoking during adolescence may influence offspring’s health through transmittable epigenetic changes in sperm precursor cells. We evaluated the three-generation associations of tobacco smoking with asthma. Methods: Between 2010 and 2013, at the European Community Respiratory Health Survey III clinical interview, 2233 mothers and 1964 fathers from 26 centres reported whether their offspring (aged ≤51 years) had ever had asthma and whether it had coexisted with nasal allergies or not. Mothers and fathers also provided information on their parents’ (grandparents) and their own asthma, education and smoking history. Multilevel mediation models within a multicentre three-generation framework were fitted separately within the maternal (4666 offspring) and paternal (4192 offspring) lines. Results: Fathers’ smoking before they were 15 [relative risk ratio (RRR) = 1.43, 95% confidence interval (CI): 1.01–2.01] and mothers’ smoking during pregnancy (RRR = 1.27, 95% CI: 1.01-1.59) were associated with asthma without nasal allergies in their offspring. Grandmothers’ smoking during pregnancy was associated with asthma in their daughters [odds ratio (OR) = 1.55, 95% CI: 1.17-2.06] and with asthma with nasal allergies in their grandchildren within the maternal line (RRR = 1.25, 95% CI: 1.02-1.55). Conclusions: Fathers’ smoking during early adolescence and grandmothers’ and mothers’ smoking during pregnancy may independently increase asthma risk in offspring. Thus, risk factors for asthma should be sought in both parents and before conception.
URI: https://digitalcollection.zhaw.ch/handle/11475/14456
Fulltext version: Published version
License (according to publishing contract): CC BY-NC 4.0: Attribution - Non commercial 4.0 International
Departement: School of Health Sciences
Organisational Unit: Institute of Public Health (IPH)
Appears in collections:Publikationen Gesundheit

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Accordini, S., Calciano, L., Johannessen, A., Portas, L., Benediktsdóttir, B., Bertelsen, R. J., Bråbäck, L., Carsin, A.-E., Dharmage, S. C., Dratva, J., Forsberg, B., Gomez Real, F., Heinrich, J., Holloway, J. W., Holm, M., Janson, C., Jögi, R., Leynaert, B., Malinovschi, A., et al. (2018). A three-generation study on the association of tobacco smoking with asthma. International Journal of Epidemiology, 47(4), 1106–1117. https://doi.org/10.1093/ije/dyy031
Accordini, S. et al. (2018) ‘A three-generation study on the association of tobacco smoking with asthma’, International Journal of Epidemiology, 47(4), pp. 1106–1117. Available at: https://doi.org/10.1093/ije/dyy031.
S. Accordini et al., “A three-generation study on the association of tobacco smoking with asthma,” International Journal of Epidemiology, vol. 47, no. 4, pp. 1106–1117, 2018, doi: 10.1093/ije/dyy031.
ACCORDINI, Simone, Lucia CALCIANO, Ane JOHANNESSEN, Laura PORTAS, Bryndis BENEDIKTSDÓTTIR, Randi Jacobsen BERTELSEN, Lennart BRÅBÄCK, Anne-Elie CARSIN, Shyamali C DHARMAGE, Julia DRATVA, Bertil FORSBERG, Francisco GOMEZ REAL, Joachim HEINRICH, John W HOLLOWAY, Mathias HOLM, Christer JANSON, Rain JÖGI, Bénédicte LEYNAERT, Andrei MALINOVSCHI, Alessandro MARCON, Jesús MARTÍNEZ-MORATALLA ROVIRA, Chantal RAHERISON, José Luis SÁNCHEZ-RAMOS, Vivi SCHLÜNSSEN, Roberto BONO, Angelo G CORSICO, Pascal DEMOLY, Sandra DORADO ARENAS, Dennis NOWAK, Isabelle PIN, Joost WEYLER, Deborah JARVIS und Cecilie SVANES, 2018. A three-generation study on the association of tobacco smoking with asthma. International Journal of Epidemiology. 2018. Bd. 47, Nr. 4, S. 1106–1117. DOI 10.1093/ije/dyy031
Accordini, Simone, Lucia Calciano, Ane Johannessen, Laura Portas, Bryndis Benediktsdóttir, Randi Jacobsen Bertelsen, Lennart Bråbäck, et al. 2018. “A Three-Generation Study on the Association of Tobacco Smoking with Asthma.” International Journal of Epidemiology 47 (4): 1106–17. https://doi.org/10.1093/ije/dyy031.
Accordini, Simone, et al. “A Three-Generation Study on the Association of Tobacco Smoking with Asthma.” International Journal of Epidemiology, vol. 47, no. 4, 2018, pp. 1106–17, https://doi.org/10.1093/ije/dyy031.


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