|Title:||Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes|
|Authors :||Schirmer, Cedric|
|Published in :||Chemie Ingenieur Technik|
|Publisher / Ed. Institution :||Wiley-VCH Verlag GmbH & Co. KGaA|
|Publisher / Ed. Institution:||Weinheim|
|License (according to publishing contract) :||Licence according to publishing contract|
|Type of review:||Peer review (Publication)|
|Subject (DDC) :||660.6: Biotechnology|
|Abstract:||An in 2016 published DECHEMA guideline concerning process engineering characterization and a new Escherichia coli model process were utilized for the qualification of two geometrically similar stirred stainless steel bioreactors (30 L and 100 L working volume). The achieved results demonstrate that performing an additional biological model process is a valuable complement to the process engineering characterization. Optical densities of 27 (100 L) and 39 (30 L) were reached in the batch cultivation process.|
|Departement:||Life Sciences und Facility Management|
|Organisational Unit:||Institute of Chemistry and Biotechnology (ICBT)|
|Publication type:||Article in scientific Journal|
|Appears in Collections:||Publikationen Life Sciences und Facility Management|
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