Title: Standardized qualification of stirred bioreactors for microbial biopharmaceutical production processes
Authors : Schirmer, Cedric
Blaschczok, Katharina
Husemann, Ute
Leupold, Marco
Zahnow, Christian
Rupprecht, Jens
Glöckler, Rainer
Greller, Gerhard
Pörtner, Ralf
Eibl-Schindler, Regine
Eibl, Dieter
Published in : Chemie Ingenieur Technik
Publisher / Ed. Institution : Wiley-VCH Verlag GmbH & Co. KGaA
Publisher / Ed. Institution: Weinheim
Issue Date: 20-Oct-2017
Language : Englisch / English
Subject (DDC) : 660.6: Biotechnologie
Abstract: An in 2016 published DECHEMA guideline concerning process engineering characterization and a new Escherichia coli model process were utilized for the qualification of two geometrically similar stirred stainless steel bioreactors (30 L and 100 L working volume). The achieved results demonstrate that performing an additional biological model process is a valuable complement to the process engineering characterization. Optical densities of 27 (100 L) and 39 (30 L) were reached in the batch cultivation process.
Departement: Life Sciences und Facility Management
Organisational Unit: Institut für Chemie und Biotechnologie (ICBT)
Publication type: Beitrag in wissenschaftlicher Zeitschrift / Article in scientific Journal
DOI : 10.1002/cite.201700039
ISSN: 0009-286X
URI: https://digitalcollection.zhaw.ch/handle/11475/1431
Appears in Collections:Publikationen Life Sciences und Facility Management

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