| Publication type: | Article in scientific journal |
| Type of review: | Peer review (publication) |
| Title: | (Metallo)porphyrins as potent phototoxic anti-cancer agents after irradiation with red light |
| Authors: | Antoni, PM Naik, A Albert, Ina Rubbiani, R Gupta, S Ruiz-Sanchez, P Munikorn, P Mateos, JM Luginbühl, Vera Thamyongkit, P Ziegler, U Gasser, G Jeschke, G Spingler, Bernhard |
| DOI: | 10.1002/chem.201405470 |
| Published in: | Chemistry - A European Journal |
| Volume(Issue): | 21 |
| Issue: | 3 |
| Page(s): | 1 |
| Pages to: | 6 |
| Issue Date: | 2014 |
| Publisher / Ed. Institution: | Wiley |
| ISSN: | 1521-3765 0947-6539 |
| Language: | English |
| Subjects: | EPR spectroscopy; Photodynamic therapy; Porphyrinoids; Anticancer agents; Fluorescence guided surgery; Porphyrine |
| Subject (DDC): | 540: Chemistry 615: Pharmacology and therapeutics |
| Abstract: | Novel photoactive (metallo)porphyrins were synthesised and characterised. When irradiated with light at a wavelength greater than 600 nm, these porphyrins act as photosensitisers and show high cytotoxicity towards two different human cancer cell lines with IC50 values down to 0.4 μM. A paramagnetic copper(II) porphyrin is the first photosensitiser to display excellent phototoxicity, explained by the electron paramagnetic resonance (EPR) spin trapping of hydroxy radicals and experimentally confirmed by the discovery of elevated levels of reactive oxygen species (ROS) inside A2780 cells after irradiation with red light. This finding indicates that paramagnetic compounds should be considered for photodynamic therapy (PDT). Furthermore, an additive effect of cisplatin and a zinc porphyrin, both at subtherapeutic concentrations of 0.22 μm, was observed. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/12931 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
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Antoni, P., Naik, A., Albert, I., Rubbiani, R., Gupta, S., Ruiz-Sanchez, P., Munikorn, P., Mateos, J., Luginbühl, V., Thamyongkit, P., Ziegler, U., Gasser, G., Jeschke, G., & Spingler, B. (2014). (Metallo)porphyrins as potent phototoxic anti-cancer agents after irradiation with red light. Chemistry - A European Journal, 21(3), 1–6. https://doi.org/10.1002/chem.201405470
Antoni, P. et al. (2014) ‘(Metallo)porphyrins as potent phototoxic anti-cancer agents after irradiation with red light’, Chemistry - A European Journal, 21(3), pp. 1–6. Available at: https://doi.org/10.1002/chem.201405470.
P. Antoni et al., “(Metallo)porphyrins as potent phototoxic anti-cancer agents after irradiation with red light,” Chemistry - A European Journal, vol. 21, no. 3, pp. 1–6, 2014, doi: 10.1002/chem.201405470.
ANTONI, PM, A NAIK, Ina ALBERT, R RUBBIANI, S GUPTA, P RUIZ-SANCHEZ, P MUNIKORN, JM MATEOS, Vera LUGINBÜHL, P THAMYONGKIT, U ZIEGLER, G GASSER, G JESCHKE und Bernhard SPINGLER, 2014. (Metallo)porphyrins as potent phototoxic anti-cancer agents after irradiation with red light. Chemistry - A European Journal. 2014. Bd. 21, Nr. 3, S. 1–6. DOI 10.1002/chem.201405470
Antoni, PM, A Naik, Ina Albert, R Rubbiani, S Gupta, P Ruiz-Sanchez, P Munikorn, et al. 2014. “(Metallo)porphyrins as Potent Phototoxic Anti-Cancer Agents after Irradiation with Red Light.” Chemistry - A European Journal 21 (3): 1–6. https://doi.org/10.1002/chem.201405470.
Antoni, PM, et al. “(Metallo)porphyrins as Potent Phototoxic Anti-Cancer Agents after Irradiation with Red Light.” Chemistry - A European Journal, vol. 21, no. 3, 2014, pp. 1–6, https://doi.org/10.1002/chem.201405470.
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