Title: The collagen suprafamily : from biosynthesis to advanced biomaterial development
Authors : Sorushanova, Anna
Delgado, Luis M.
Wu, Zhuning
Shologu, Naledi
Kshirsagar, Aniket
Raghunath, Rufus
Mullen, Anne M.
Bayon, Yves
Pandit, Abhay
Raghunath, Michael
Zeugolis, Dimitrios I.
Published in : Advanced Materials
Publisher / Ed. Institution : Wiley
Issue Date: 2018
License (according to publishing contract) : Licence according to publishing contract
Type of review: Peer review (publication)
Language : English
Subject (DDC) : 571: Physiology and related subjects
Abstract: Biomimetic microenvironments are key components to successful cell culture and tissue engineering in vitro. One of the most accurate biomimetic microenvironments is that made by the cells themselves. Cell-made microenvironments are most similar to the in vivo state as they are cell-specific and produced by the actual cells which reside in that specific microenvironment. However, cell-made microenvironments have been challenging to re-create in vitro due to the lack of extracellular matrix composition, volume and complexity which are required. By applying macromolecular crowding to current cell culture protocols, cell-made microenvironments, or cell-derived matrices, can be generated at significant rates in vitro. In this review, we will examine the causes and effects of macromolecular crowding and how it has been applied in several in vitro systems including tissue engineering.
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Publication type: Article in scientific journal
DOI : 10.1002/adma.201801651
ISSN: 0935-9648
URI: https://digitalcollection.zhaw.ch/handle/11475/12108
Appears in Collections:Publikationen Life Sciences und Facility Management

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