Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Current and upcoming therapies to modulate skin scarring and fibrosis
Authors: Coentro, João Q.
Pugliese, Eugenia
Hanley, Geoffrey
Raghunath, Michael
Zeugolis, Dimitrios I.
DOI: 10.1016/j.addr.2018.08.009
Published in: Advanced Drug Delivery Reviews
Issue Date: 2018
Publisher / Ed. Institution: Elsevier
ISSN: 0169-409X
Language: English
Subject (DDC): 617: Surgery
Abstract: Skin is the largest organ of the human body. Being the interface between the body and the outer environment, makes it susceptible to physical injury. To maintain life, nature has endowed skin with a fast healing response that invariably ends in the formation of scar at the wounded dermal area. In many cases, skin remodelling may be impaired, leading to local hypertrophic scars or keloids. One should also consider that the scarring process is part of the wound healing response, which always starts with inflammation. Thus, scarring can also be induced in the dermis, in the absence of an actual wound, during chronic inflammatory processes. Considering the significant portion of the population that is subject to abnormal scarring, this review critically discusses the state-of-the-art and upcoming therapies in skin scarring and fibrosis.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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