|Title:||Clinical data sharing : a data scientist's perspective|
|Authors :||Juchler, Norman|
|Conference details:||Life in Numbers 4, ZHAW, Waedenswil, 4 October 2018|
|License (according to publishing contract) :||Not specified|
|Type of review:||No review|
|Subjects :||Intracranial aneurysms; Clinical data sharing|
|Subject (DDC) :||005: Computer programming, programs and data |
610: Medicine and health
|Abstract:||An ever increasing amount of medical data is collected and used for scientific and clinical purposes. To benefit from the abundance of data, however, one has to deal with several challenges. The diversity of data sources, the variability seen in the biological systems and the biases and distortions inherent in the acquired data request for robust and flexible data processing pipelines. Here, we illustrate some of these challenges at the hand of our research on intracranial aneurysms and share insights how to deal with these challenges. We present the AneuX AneurysmDataBase. It stores data acquired at multiple clinical centers, supports heterogeneous data (clinical data, imaging data, genetic data, morphological and histological data, etc.) and is aimed for use in both scientific and industrial contexts. We further present five scientific studies that demonstrate the usage of the AneurysmDataBase. In the first application, we evaluated the PHASES score, a recent scoring scheme to guide the clinicians whether to treat an unruptured intracranial aneurysm. We further examined and improved existing morphological descriptors with the goal to associate aneurysm shape with its disease status. In a third study, we quantified the qualitative rating of aneurysm shape by humans. A fourth study aims at inferring information about the disease directly from imaging data by means of convolutional neural nets. Finally, we sketch how to query aneurysms with similar anatomical and morphological properties from a database. With our work, we demonstrate how clinical data sharing can be used for quantitative analyses of aneurysm properties and for the development of diagnostic and prognostic tools.|
|Departement:||Life Sciences and Facility Management|
|Organisational Unit:||Institute of Applied Simulation (IAS)|
|Publication type:||Conference Other|
|Appears in Collections:||Publikationen Life Sciences und Facility Management|
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