Publication type: Conference poster
Type of review: Peer review (abstract)
Title: What's ugly? : shape-based analysis of intracranial aneurysms
Authors: Juchler, Norman
Schilling, Sabine
Vartan, Kurtcuoglu
Hirsch, Sven
Conference details: Latsis Symposium 2016 : Personalized Medicine, Zurich, 27-29 June 2016
Issue Date: 29-Jun-2016
Language: English
Subjects: Shape-based risk assessment; Intracranial aneurysms
Subject (DDC): 616: Internal medicine and diseases
Abstract: It is exceedingly challenging to assess the clinical significance of intracranial aneurysms. Currently, clinicians associate aneurysm shape irregularity with wall instability. However, there is no consensus on which shape features reliably predict aneurysm rupture risk. Here we present a machine learning approach to tackle this problem: We implemented a classification pipeline to identify shape features with predictive power of aneurysm instability. 3D models of aneurysms are extracted from medical imaging data (mostly 3D rotational angiography) using a standardized vessel segmentation protocol. A variety of established representations of the 3D shape are calculated for the extracted aneurysm segment. These include the calculation of Zernike moment invariants (ZMI) and simpler geometry indices such as undulation, ellipticity and non-sphericity. Feature reduction techniques (for ZMI) and classification methods are applied to find patterns linking shape features to aneurysm stability in an exploratory way. This processing pipeline was applied to a clinical dataset of approximately 250 aneurysms registered in the AneurysmDataBase (SwissNeuroFoundation) and AneuriskWeb database. Classification based on ZMI alone allowed us to distinguish between sidewall and bifurcation aneurysms, but failed to forecast an aneurysm’s rupture status reliably. Remarkably, simpler geometry indices performed similarly well in rupture status prediction. It remains to be investigated whether further stratification of the aneurysms in terms of location, size and clinical factors will increase the robustness of the applied classification methods. This study was performed within the scope of the AneuX project, funded by, and received support by SNSF NCCR Kidney.CH. 
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Computational Life Sciences (ICLS)
Published as part of the ZHAW project: AneuX
Appears in collections:Publikationen Life Sciences und Facility Management

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