| Publikationstyp: | Konferenz: Poster |
| Art der Begutachtung: | Peer review (Abstract) |
| Titel: | What's ugly? : shape-based analysis of intracranial aneurysms |
| Autor/-in: | Juchler, Norman Schilling, Sabine Vartan, Kurtcuoglu Hirsch, Sven |
| Angaben zur Konferenz: | Latsis Symposium 2016 : Personalized Medicine, Zurich, 27-29 June 2016 |
| Erscheinungsdatum: | 29-Jun-2016 |
| Sprache: | Englisch |
| Schlagwörter: | Shape-based risk assessment; Intracranial aneurysms |
| Fachgebiet (DDC): | 616: Innere Medizin und Krankheiten |
| Zusammenfassung: | It is exceedingly challenging to assess the clinical significance of intracranial aneurysms. Currently, clinicians associate aneurysm shape irregularity with wall instability. However, there is no consensus on which shape features reliably predict aneurysm rupture risk. Here we present a machine learning approach to tackle this problem: We implemented a classification pipeline to identify shape features with predictive power of aneurysm instability. 3D models of aneurysms are extracted from medical imaging data (mostly 3D rotational angiography) using a standardized vessel segmentation protocol. A variety of established representations of the 3D shape are calculated for the extracted aneurysm segment. These include the calculation of Zernike moment invariants (ZMI) and simpler geometry indices such as undulation, ellipticity and non-sphericity. Feature reduction techniques (for ZMI) and classification methods are applied to find patterns linking shape features to aneurysm stability in an exploratory way. This processing pipeline was applied to a clinical dataset of approximately 250 aneurysms registered in the AneurysmDataBase (SwissNeuroFoundation) and AneuriskWeb database. Classification based on ZMI alone allowed us to distinguish between sidewall and bifurcation aneurysms, but failed to forecast an aneurysm’s rupture status reliably. Remarkably, simpler geometry indices performed similarly well in rupture status prediction. It remains to be investigated whether further stratification of the aneurysms in terms of location, size and clinical factors will increase the robustness of the applied classification methods. This study was performed within the scope of the AneuX project, funded by SystemsX.ch, and received support by SNSF NCCR Kidney.CH. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/12074 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Computational Life Sciences (ICLS) |
| Publiziert im Rahmen des ZHAW-Projekts: | AneuX |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
Es gibt keine Dateien zu dieser Ressource.
Zur Langanzeige
Juchler, N., Schilling, S., Vartan, K., & Hirsch, S. (2016, June 29). What’s ugly? : shape-based analysis of intracranial aneurysms. Latsis Symposium 2016 : Personalized Medicine, Zurich, 27-29 June 2016.
Juchler, N. et al. (2016) ‘What’s ugly? : shape-based analysis of intracranial aneurysms’, in Latsis Symposium 2016 : Personalized Medicine, Zurich, 27-29 June 2016.
N. Juchler, S. Schilling, K. Vartan, and S. Hirsch, “What’s ugly? : shape-based analysis of intracranial aneurysms,” in Latsis Symposium 2016 : Personalized Medicine, Zurich, 27-29 June 2016, Jun. 2016.
JUCHLER, Norman, Sabine SCHILLING, Kurtcuoglu VARTAN und Sven HIRSCH, 2016. What’s ugly? : shape-based analysis of intracranial aneurysms. In: Latsis Symposium 2016 : Personalized Medicine, Zurich, 27-29 June 2016. Conference poster. 29 Juni 2016
Juchler, Norman, Sabine Schilling, Kurtcuoglu Vartan, and Sven Hirsch. 2016. “What’s Ugly? : Shape-Based Analysis of Intracranial Aneurysms.” Conference poster. In Latsis Symposium 2016 : Personalized Medicine, Zurich, 27-29 June 2016.
Juchler, Norman, et al. “What’s Ugly? : Shape-Based Analysis of Intracranial Aneurysms.” Latsis Symposium 2016 : Personalized Medicine, Zurich, 27-29 June 2016, 2016.
Alle Ressourcen in diesem Repository sind urheberrechtlich geschützt, soweit nicht anderweitig angezeigt.