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https://doi.org/10.21256/zhaw-3822Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Laternser, Sandra | - |
| dc.contributor.author | Keller, Hansjoerg | - |
| dc.contributor.author | Leupin, Olivier | - |
| dc.contributor.author | Rausch, Martin | - |
| dc.contributor.author | Graf-Hausner, Ursula | - |
| dc.contributor.author | Rimann, Markus | - |
| dc.date.accessioned | 2018-07-03T14:18:29Z | - |
| dc.date.available | 2018-07-03T14:18:29Z | - |
| dc.date.issued | 2018-06-12 | - |
| dc.identifier.issn | 2472-6303 | de_CH |
| dc.identifier.issn | 2472-6311 | de_CH |
| dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/7548 | - |
| dc.description.abstract | Two-dimensional (2D) cell cultures do not reflect the in vivo situation, and thus it is important to develop predictive three-dimensional (3D) in vitro models with enhanced reliability and robustness for drug screening applications. Treatments against muscle-related diseases are becoming more prominent due to the growth of the aging population worldwide. In this study, we describe a novel drug screening platform with automated production of 3D musculoskeletal-tendon-like tissues. With 3D bioprinting, alternating layers of photo-polymerized gelatin-methacryloyl-based bioink and cell suspension tissue models were produced in a dumbbell shape onto novel postholder cell culture inserts in 24-well plates. Monocultures of human primary skeletal muscle cells and rat tenocytes were printed around and between the posts. The cells showed high viability in culture and good tissue differentiation, based on marker gene and protein expressions. Different printing patterns of bioink and cells were explored and calcium signaling with Fluo4-loaded cells while electrically stimulated was shown. Finally, controlled co-printing of tenocytes and myoblasts around and between the posts, respectively, was demonstrated followed by co-culture and co-differentiation. This screening platform combining 3D bioprinting with a novel microplate represents a promising tool to address musculoskeletal diseases. | de_CH |
| dc.language.iso | en | de_CH |
| dc.publisher | Sage | de_CH |
| dc.relation.ispartof | SLAS Technology: Translating Life Sciences Innovation | de_CH |
| dc.rights | http://creativecommons.org/licenses/by-nc/4.0/ | de_CH |
| dc.subject | 3D bioprinting | de_CH |
| dc.subject | 3D cell culture | de_CH |
| dc.subject | Bioink | de_CH |
| dc.subject | Drug development | de_CH |
| dc.subject | Muscle tissue engineering | de_CH |
| dc.subject.ddc | 610: Medizin und Gesundheit | de_CH |
| dc.title | A novel microplate 3D bioprinting platform for the engineering of muscle and tendon tissues | de_CH |
| dc.type | Beitrag in wissenschaftlicher Zeitschrift | de_CH |
| dcterms.type | Text | de_CH |
| zhaw.departement | Life Sciences und Facility Management | de_CH |
| zhaw.organisationalunit | Institut für Chemie und Biotechnologie (ICBT) | de_CH |
| dc.identifier.doi | 10.21256/zhaw-3822 | - |
| dc.identifier.doi | 10.1177/2472630318776594 | de_CH |
| dc.identifier.pmid | 29895208 | de_CH |
| zhaw.funding.eu | No | de_CH |
| zhaw.issue | 6 | de_CH |
| zhaw.originated.zhaw | Yes | de_CH |
| zhaw.pages.end | 613 | de_CH |
| zhaw.pages.start | 599 | de_CH |
| zhaw.publication.status | publishedVersion | de_CH |
| zhaw.volume | 23 | de_CH |
| zhaw.publication.review | Peer review (Publikation) | de_CH |
| zhaw.webfeed | 3D Gewebe und Biofabrikation | de_CH |
| Appears in collections: | Publikationen Life Sciences und Facility Management | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| Laternser2018 muscle bioprinting.pdf | 974.23 kB | Adobe PDF |  View/Open |
Show simple item record
Laternser, S., Keller, H., Leupin, O., Rausch, M., Graf-Hausner, U., & Rimann, M. (2018). A novel microplate 3D bioprinting platform for the engineering of muscle and tendon tissues. SLAS Technology: Translating Life Sciences Innovation, 23(6), 599–613. https://doi.org/10.21256/zhaw-3822
Laternser, S. et al. (2018) ‘A novel microplate 3D bioprinting platform for the engineering of muscle and tendon tissues’, SLAS Technology: Translating Life Sciences Innovation, 23(6), pp. 599–613. Available at: https://doi.org/10.21256/zhaw-3822.
S. Laternser, H. Keller, O. Leupin, M. Rausch, U. Graf-Hausner, and M. Rimann, “A novel microplate 3D bioprinting platform for the engineering of muscle and tendon tissues,” SLAS Technology: Translating Life Sciences Innovation, vol. 23, no. 6, pp. 599–613, Jun. 2018, doi: 10.21256/zhaw-3822.
LATERNSER, Sandra, Hansjoerg KELLER, Olivier LEUPIN, Martin RAUSCH, Ursula GRAF-HAUSNER und Markus RIMANN, 2018. A novel microplate 3D bioprinting platform for the engineering of muscle and tendon tissues. SLAS Technology: Translating Life Sciences Innovation. 12 Juni 2018. Bd. 23, Nr. 6, S. 599–613. DOI 10.21256/zhaw-3822
Laternser, Sandra, Hansjoerg Keller, Olivier Leupin, Martin Rausch, Ursula Graf-Hausner, and Markus Rimann. 2018. “A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues.” SLAS Technology: Translating Life Sciences Innovation 23 (6): 599–613. https://doi.org/10.21256/zhaw-3822.
Laternser, Sandra, et al. “A Novel Microplate 3D Bioprinting Platform for the Engineering of Muscle and Tendon Tissues.” SLAS Technology: Translating Life Sciences Innovation, vol. 23, no. 6, June 2018, pp. 599–613, https://doi.org/10.21256/zhaw-3822.
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