| Publication type: | Book part |
| Type of review: | Editorial review |
| Title: | Computational aids for assessing bioactivities |
| Authors: | Wolfram, Evelyn Trifan, Adriana |
| DOI: | 10.1016/B978-0-12-812364-5.00010-9 |
| Published in: | Computational phytochemistry |
| Editors of the parent work: | Sarker, Satyajit Nahar, Lutfun |
| Page(s): | 277 |
| Pages to: | 300 |
| Issue Date: | 2018 |
| Publisher / Ed. Institution: | Elsevier |
| Publisher / Ed. Institution: | Amsterdam |
| ISBN: | 978-0-12-812364-5 |
| Language: | English |
| Subjects: | In vitro bioassays; In silico screening; Databases and data analysis; Bioinformatics; Modelling; Statistical tool; Data mining; Bioprospecting |
| Subject (DDC): | 572: Biochemistry |
| Abstract: | Bioactivity assessment requires test systems, which are often representative for phenomena in the human body or other target organisms, like microbes. They involve the acquisition of signals, mainly spectrophotometric, or luminometric, in parallel experiments (e.g., microtitre plates) from different concentrations of the test samples and the comparison to blanks and positive controls. In such complex settings, computational aids are needed for the handling, storage, sorting, and visualization of the data and to help to apply suitable mathematical or statistical models to interpret and evaluate the findings and correlate data sets and signals of different origins. In the case of bioactivity assessment of natural products, the complexity of the multicompound mixture in natural extracts and fractions requires computational tools on different levels of the scientific challenge, such as text and data mining, in silico screening by target-ligand docking, as well as chemometrics and multivariate data analysis. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/6892 |
| Fulltext version: | Published version |
| License (according to publishing contract): | Licence according to publishing contract |
| Departement: | Life Sciences and Facility Management |
| Organisational Unit: | Institute of Chemistry and Biotechnology (ICBT) |
| Appears in collections: | Publikationen Life Sciences und Facility Management |
Files in This Item:
There are no files associated with this item.
Show full item record
Wolfram, E., & Trifan, A. (2018). Computational aids for assessing bioactivities. In S. Sarker & L. Nahar (Eds.), Computational phytochemistry (pp. 277–300). Elsevier. https://doi.org/10.1016/B978-0-12-812364-5.00010-9
Wolfram, E. and Trifan, A. (2018) ‘Computational aids for assessing bioactivities’, in S. Sarker and L. Nahar (eds) Computational phytochemistry. Amsterdam: Elsevier, pp. 277–300. Available at: https://doi.org/10.1016/B978-0-12-812364-5.00010-9.
E. Wolfram and A. Trifan, “Computational aids for assessing bioactivities,” in Computational phytochemistry, S. Sarker and L. Nahar, Eds. Amsterdam: Elsevier, 2018, pp. 277–300. doi: 10.1016/B978-0-12-812364-5.00010-9.
WOLFRAM, Evelyn und Adriana TRIFAN, 2018. Computational aids for assessing bioactivities. In: Satyajit SARKER und Lutfun NAHAR (Hrsg.), Computational phytochemistry. Amsterdam: Elsevier. S. 277–300. ISBN 978-0-12-812364-5
Wolfram, Evelyn, and Adriana Trifan. 2018. “Computational Aids for Assessing Bioactivities.” In Computational Phytochemistry, edited by Satyajit Sarker and Lutfun Nahar, 277–300. Amsterdam: Elsevier. https://doi.org/10.1016/B978-0-12-812364-5.00010-9.
Wolfram, Evelyn, and Adriana Trifan. “Computational Aids for Assessing Bioactivities.” Computational Phytochemistry, edited by Satyajit Sarker and Lutfun Nahar, Elsevier, 2018, pp. 277–300, https://doi.org/10.1016/B978-0-12-812364-5.00010-9.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.