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https://doi.org/10.21256/zhaw-6803| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition |
| Autor/-in: | Schaub, Beat E. Berger, Eric G. Rohrer, Jack |
| DOI: | 10.1007/s00018-008-8446-y 10.21256/zhaw-6803 |
| Erschienen in: | Cellular and Molecular Life Sciences |
| Band(Heft): | 65 |
| Heft: | 22 |
| Seite(n): | 3677 |
| Seiten bis: | 3687 |
| Erscheinungsdatum: | Nov-2008 |
| Verlag / Hrsg. Institution: | Springer |
| ISSN: | 1420-9071 1420-682X |
| Sprache: | Englisch |
| Schlagwörter: | Golgi Apparatus; Sorting signal; Trafficking; Glycosyltransferases; Monensin |
| Fachgebiet (DDC): | 571: Physiologie und verwandte Themen |
| Zusammenfassung: | Two major functions of the Golgi apparatus (GA) are formation of complex glycans and sorting of proteins destined for various subcellular compartments or secretion. To fulfill these tasks proper localization of the accessory proteins within the different sub-compartments of the GA is crucial. Here we investigate structural determinants mediating transition of the two glycosyltransferases beta-1,4- galactosyltransferase 1 (gal-T1) and the alpha-1,3-fucosyltransferase 6 (fuc-T6) from the trans-Golgi cisterna to the trans-Golgi network (TGN). Upon treatment with the ionophore monensin both glycosyltransferases are found in TGN-derived swollen vesicles, as determined by confocal fluorescence microscopy and density gradient fractionation. Both enzymes carry a signal consisting of the amino acids E(5)P(6) in gal-T1 and D(2)P(3) in fuc-T6 necessary for the transition of these glycosyltransferases from the trans-Golgi cisterna to the TGN, but not for their steady state localization in the trans-Golgi cisterna. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/6803 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Life Sciences und Facility Management |
| Organisationseinheit: | Institut für Chemie und Biotechnologie (ICBT) |
| Enthalten in den Sammlungen: | Publikationen Life Sciences und Facility Management |
Dateien zu dieser Ressource:
| Datei | Beschreibung | Größe | Format | |
|---|---|---|---|---|
| 2008_Schaub-etal_Golgi-to-transGolgi-network-transition.pdf | 2.54 MB | Adobe PDF |  Öffnen/Anzeigen |
Zur Langanzeige
Schaub, B. E., Berger, E. G., & Rohrer, J. (2008). Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition. Cellular and Molecular Life Sciences, 65(22), 3677–3687. https://doi.org/10.1007/s00018-008-8446-y
Schaub, B.E., Berger, E.G. and Rohrer, J. (2008) ‘Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition’, Cellular and Molecular Life Sciences, 65(22), pp. 3677–3687. Available at: https://doi.org/10.1007/s00018-008-8446-y.
B. E. Schaub, E. G. Berger, and J. Rohrer, “Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition,” Cellular and Molecular Life Sciences, vol. 65, no. 22, pp. 3677–3687, Nov. 2008, doi: 10.1007/s00018-008-8446-y.
SCHAUB, Beat E., Eric G. BERGER und Jack ROHRER, 2008. Dissection of a novel molecular determinant mediating Golgi to trans-Golgi network transition. Cellular and Molecular Life Sciences. November 2008. Bd. 65, Nr. 22, S. 3677–3687. DOI 10.1007/s00018-008-8446-y
Schaub, Beat E., Eric G. Berger, and Jack Rohrer. 2008. “Dissection of a Novel Molecular Determinant Mediating Golgi to Trans-Golgi Network Transition.” Cellular and Molecular Life Sciences 65 (22): 3677–87. https://doi.org/10.1007/s00018-008-8446-y.
Schaub, Beat E., et al. “Dissection of a Novel Molecular Determinant Mediating Golgi to Trans-Golgi Network Transition.” Cellular and Molecular Life Sciences, vol. 65, no. 22, Nov. 2008, pp. 3677–87, https://doi.org/10.1007/s00018-008-8446-y.
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