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dc.contributor.authorSpaeth, Nicolas-
dc.contributor.authorWyss, Matthias T.-
dc.contributor.authorWeber, Bruno-
dc.contributor.authorScheidegger, Stephan-
dc.contributor.authorLutz, Amelie-
dc.contributor.authorVerwey, Jorn-
dc.contributor.authorRadovanovic, Ivan-
dc.contributor.authorPahnke, Jens-
dc.contributor.authorWild, Damian-
dc.contributor.authorWestera, Gerrit-
dc.contributor.authorWeishaupt, Dominik-
dc.contributor.authorHermann, Dirk M.-
dc.contributor.authorKaser-Hotz, Barbara-
dc.contributor.authorAguzzi, Adriano-
dc.contributor.authorBuck, Alfred-
dc.date.accessioned2018-03-08T12:48:47Z-
dc.date.available2018-03-08T12:48:47Z-
dc.date.issued2004-
dc.identifier.issn0161-5505de_CH
dc.identifier.issn1535-5667de_CH
dc.identifier.urihttp://jnm.snmjournals.org/content/45/11/1931.full.pdf+htmlde_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/3535-
dc.description.abstractDifferentiation between posttherapy radiation necrosis and recurrent tumor in humans with brain tumor is still a difficult diagnostic task. The new PET tracers 18F-fluoro-ethyl-l-tyrosine (FET) and 18F-fluorocholine (N,N-dimethyl-N-18F-fluoromethyl-2-hydroxyethylammonium [FCH]) have shown promise for improving diagnostic accuracy. This study assessed uptake of these tracers in experimental radiation injury. Methods: In a first model, circumscribed lesions were induced in the cortex of 35 rats using proton irradiation of 150 or 250 Gy. After radiation injury developed, uptake of 18F-FET, 18F-FCH, and 18F-FDG was measured using autoradiography and correlated with histology and disruption of the blood-brain barrier as determined with Evans blue. In a second model, uptake of the tracers was assessed in acute cryolesions, which are characterized by the absence of inflammatory cells. Results: Mean 18F-FET, 18F-FCH, and 18F-FDG standardized uptake values in the most active part of the radiation lesion and the contralateral normal cortex (in parentheses) were 2.27 ± 0.46 (1.42 ± 0.23), 2.52 ± 0.42 (0.61 ± 0.12), and 6.21 ± 1.19 (4.35 ± 0.47). The degree of uptake of 18F-FCH and 18F-FDG correlated with the density of macrophages. In cryolesions, 18F-FET uptake was similar to that in radiation lesions, and 18F-FCH uptake was significantly reduced. Conclusion: Comparison of tracer accumulation in cryolesions and radiation injuries demonstrates that 18F-FET uptake is most likely due to a disruption of the blood-brain barrier alone, whereas 18F-FCH is additionally trapped by macrophages. Uptake of both tracers in the radiation injuries is generally lower than the published uptake in tumors, suggesting that 18F-FET and 18F-FCH are promising tracers for separating radiation necrosis from tumor recurrence. However, the comparability of our data with the literature is limited by factors such as different species and acquisition protocols and modalities. Thus, more studies are needed to settle this issue. Nevertheless, 18F-FCH and 18F-FET seem superior to 18F-FDG for this purpose.de_CH
dc.language.isoende_CH
dc.publisherSociety of Nuclear Medicinede_CH
dc.relation.ispartofJournal of Nuclear Medicinede_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectProton irradiationde_CH
dc.subjectCerebral radiation injuryde_CH
dc.subjectTumor recurrencede_CH
dc.subjectTracer for radiation necrosisde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleUptake of 18F-fluorocholine, 18F-fluoroethyl-l-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat : implications for separation of radiation necrosis from tumor recurrencede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.funding.euNode_CH
zhaw.issue11de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end1938de_CH
zhaw.pages.start1931de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume45de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
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Spaeth, N., Wyss, M. T., Weber, B., Scheidegger, S., Lutz, A., Verwey, J., Radovanovic, I., Pahnke, J., Wild, D., Westera, G., Weishaupt, D., Hermann, D. M., Kaser-Hotz, B., Aguzzi, A., & Buck, A. (2004). Uptake of 18F-fluorocholine, 18F-fluoroethyl-l-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat : implications for separation of radiation necrosis from tumor recurrence. Journal of Nuclear Medicine, 45(11), 1931–1938. http://jnm.snmjournals.org/content/45/11/1931.full.pdf+html
Spaeth, N. et al. (2004) ‘Uptake of 18F-fluorocholine, 18F-fluoroethyl-l-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat : implications for separation of radiation necrosis from tumor recurrence’, Journal of Nuclear Medicine, 45(11), pp. 1931–1938. Available at: http://jnm.snmjournals.org/content/45/11/1931.full.pdf+html.
N. Spaeth et al., “Uptake of 18F-fluorocholine, 18F-fluoroethyl-l-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat : implications for separation of radiation necrosis from tumor recurrence,” Journal of Nuclear Medicine, vol. 45, no. 11, pp. 1931–1938, 2004, [Online]. Available: http://jnm.snmjournals.org/content/45/11/1931.full.pdf+html
SPAETH, Nicolas, Matthias T. WYSS, Bruno WEBER, Stephan SCHEIDEGGER, Amelie LUTZ, Jorn VERWEY, Ivan RADOVANOVIC, Jens PAHNKE, Damian WILD, Gerrit WESTERA, Dominik WEISHAUPT, Dirk M. HERMANN, Barbara KASER-HOTZ, Adriano AGUZZI und Alfred BUCK, 2004. Uptake of 18F-fluorocholine, 18F-fluoroethyl-l-tyrosine, and 18F-FDG in acute cerebral radiation injury in the rat : implications for separation of radiation necrosis from tumor recurrence. Journal of Nuclear Medicine [online]. 2004. Bd. 45, Nr. 11, S. 1931–1938. Verfügbar unter: http://jnm.snmjournals.org/content/45/11/1931.full.pdf+html
Spaeth, Nicolas, Matthias T. Wyss, Bruno Weber, Stephan Scheidegger, Amelie Lutz, Jorn Verwey, Ivan Radovanovic, et al. 2004. “Uptake of 18F-Fluorocholine, 18F-Fluoroethyl-L-Tyrosine, and 18F-FDG in Acute Cerebral Radiation Injury in the Rat : Implications for Separation of Radiation Necrosis from Tumor Recurrence.” Journal of Nuclear Medicine 45 (11): 1931–38. http://jnm.snmjournals.org/content/45/11/1931.full.pdf+html.
Spaeth, Nicolas, et al. “Uptake of 18F-Fluorocholine, 18F-Fluoroethyl-L-Tyrosine, and 18F-FDG in Acute Cerebral Radiation Injury in the Rat : Implications for Separation of Radiation Necrosis from Tumor Recurrence.” Journal of Nuclear Medicine, vol. 45, no. 11, 2004, pp. 1931–38, http://jnm.snmjournals.org/content/45/11/1931.full.pdf+html.


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