1. ZHAW digitalcollection
  2. School of Engineering
  3. Publikationen
  4. Publikationen School of Engineering
Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-1748
Full metadata record
DC FieldValueLanguage
dc.contributor.authorMauth, C-
dc.contributor.authorBono, Epifania-
dc.contributor.authorHaas, S-
dc.contributor.authorPaesold, G.-
dc.contributor.authorWiese, H.-
dc.contributor.authorMaier, G.-
dc.contributor.authorBoos, N.-
dc.contributor.authorGraf-Hausner, Ursula-
dc.date.accessioned2018-02-27T15:19:46Z-
dc.date.available2018-02-27T15:19:46Z-
dc.date.issued2009-
dc.identifier.issn1473-2262de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/3270-
dc.description.abstractNowadays, intervertebral disc (IVD) degeneration is one of the principal causes of low back pain involving high expense within the health care system. The long-term goal is the development of a medical treatment modality focused on a more biological regeneration of the inner nucleus pulposus (NP). Hence, interest in the endoscopic implantation of an injectable material took center stage in the recent past. We report on the development of a novel polyurethane (PU) scaffold as a mechanically stable carrier system for the reimplantation of expanded autologous IVD-derived cells (disc cells) to stimulate regenerative processes and restore the chondrocyte-like tissue within the NP. Primary human disc cells were seeded into newly developed PU spheroids which were subsequently encapsulated in fibrin hydrogel. The study aims to analyze adhesion properties, proliferation capacity and phenotypic characterization of these cells. Polymerase chain reaction was carried out to detect the expression of genes specifically expressed by native IVD cells. Biochemical analyses showed an increased DNA content, and a progressive enhancement of total collagen and glycosaminoglycans (GAG) was observed during cell culture. The results suggest the synthesis of an appropriate extracellular matrix as well as a stable mRNA expression of chondrogenic and/or NP specific markers. In conclusion, the data presented indicate an alternative medical approach to current treatment options of degenerated IVD tissue.de_CH
dc.language.isoende_CH
dc.publisherSwiss Society for Biomaterialsde_CH
dc.relation.ispartofEuropean Cells & Materialsde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subject.ddc610: Medizin und Gesundheitde_CH
dc.titleCell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regenerationde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
dc.identifier.doi10.21256/zhaw-1748-
dc.identifier.doi10.22203/eCM.v018a03de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end39de_CH
zhaw.pages.start27de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume18de_CH
zhaw.publication.reviewOpen peer reviewde_CH
Appears in collections:Publikationen School of Engineering

Files in This Item:
File Description SizeFormat 
2009_Mauth_Cell-Seeded_Polyurethane_EuropeanCells.pdf552.17 kBAdobe PDFThumbnail
View/Open
Show simple item record
Mauth, C., Bono, E., Haas, S., Paesold, G., Wiese, H., Maier, G., Boos, N., & Graf-Hausner, U. (2009). Cell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regeneration. European Cells & Materials, 18, 27–39. https://doi.org/10.21256/zhaw-1748
Mauth, C. et al. (2009) ‘Cell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regeneration’, European Cells & Materials, 18, pp. 27–39. Available at: https://doi.org/10.21256/zhaw-1748.
C. Mauth et al., “Cell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regeneration,” European Cells & Materials, vol. 18, pp. 27–39, 2009, doi: 10.21256/zhaw-1748.
MAUTH, C, Epifania BONO, S HAAS, G. PAESOLD, H. WIESE, G. MAIER, N. BOOS und Ursula GRAF-HAUSNER, 2009. Cell-seeded polyurethane-fibrin structures : a possible system for intervertebral disc regeneration. European Cells & Materials. 2009. Bd. 18, S. 27–39. DOI 10.21256/zhaw-1748
Mauth, C, Epifania Bono, S Haas, G. Paesold, H. Wiese, G. Maier, N. Boos, and Ursula Graf-Hausner. 2009. “Cell-Seeded Polyurethane-Fibrin Structures : A Possible System for Intervertebral Disc Regeneration.” European Cells & Materials 18: 27–39. https://doi.org/10.21256/zhaw-1748.
Mauth, C., et al. “Cell-Seeded Polyurethane-Fibrin Structures : A Possible System for Intervertebral Disc Regeneration.” European Cells & Materials, vol. 18, 2009, pp. 27–39, https://doi.org/10.21256/zhaw-1748.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.