1. ZHAW digitalcollection
  2. Life Sciences und Facility Management
  3. Publikationen
  4. Publikationen Life Sciences und Facility Management
Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-30503
Full metadata record
DC FieldValueLanguage
dc.contributor.authorVahekeni, Nina-
dc.contributor.authorBrillatz, Théo-
dc.contributor.authorRahmaty, Marjan-
dc.contributor.authorCal, Monica-
dc.contributor.authorKeller-Maerki, Sonja-
dc.contributor.authorRocchetti, Romina-
dc.contributor.authorKaiser, Marcel-
dc.contributor.authorSax, Sibylle-
dc.contributor.authorMattli, Kevin-
dc.contributor.authorWolfram, Evelyn-
dc.contributor.authorMarcourt, Laurence-
dc.contributor.authorQueiroz, Emerson Ferreira-
dc.contributor.authorWolfender, Jean-Luc-
dc.contributor.authorMäser, Pascal-
dc.date.accessioned2024-04-26T11:54:48Z-
dc.date.available2024-04-26T11:54:48Z-
dc.date.issued2024-04-03-
dc.identifier.issn1420-3049de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/30503-
dc.description.abstractFolk medicine is widely used in Angola, even for human African trypanosomiasis (sleeping sickness) in spite of the fact that the reference treatment is available for free. Aiming to validate herbal remedies in use, we selected nine medicinal plants and assessed their antitrypanosomal activity. A total of 122 extracts were prepared using different plant parts and solvents. A total of 15 extracts from seven different plants exhibited in vitro activity (>70% at 20 µg/mL) against Trypanosoma brucei rhodesiense bloodstream forms. The dichloromethane extract of Nymphaea lotus (leaves and leaflets) and the ethanolic extract of Brasenia schreberi (leaves) had IC50 values ≤ 10 µg/mL. These two aquatic plants are of particular interest. They are being co-applied in the form of a decoction of leaves because they are considered by local healers as male and female of the same species, the ethnotaxon "longa dia simbi". Bioassay-guided fractionation led to the identification of eight active molecules: gallic acid (IC50 0.5 µg/mL), methyl gallate (IC50 1.1 µg/mL), 2,3,4,6-tetragalloyl-glucopyranoside, ethyl gallate (IC50 0.5 µg/mL), 1,2,3,4,6-pentagalloyl-β-glucopyranoside (IC50 20 µg/mL), gossypetin-7-O-β-glucopyranoside (IC50 5.5 µg/mL), and hypolaetin-7-O-glucoside (IC50 5.7 µg/mL) in B. schreberi, and 5-[(8Z,11Z,14Z)-heptadeca-8,11,14-trienyl] resorcinol (IC50 5.3 µg/mL) not described to date in N. lotus. Five of these active constituents were detected in the traditional preparation. This work provides the first evidence for the ethnomedicinal use of these plants in the management of sleeping sickness in Angola.de_CH
dc.language.isoende_CH
dc.publisherMDPIde_CH
dc.relation.ispartofMoleculesde_CH
dc.rightshttps://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectAfrican medicinal plantde_CH
dc.subjectAngolade_CH
dc.subjectBrasenia schreberide_CH
dc.subjectNymphaea lotusde_CH
dc.subjectEthnopharmacologyde_CH
dc.subjectTrypanosomiasisde_CH
dc.subjectHumansde_CH
dc.subjectAnimalde_CH
dc.subjectSeedde_CH
dc.subjectPlant extractde_CH
dc.subjectTrypanosomiasis, Africande_CH
dc.subjectAntiprotozoal agentde_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleAntiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. active against T. b. rhodesiensede_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.3390/molecules29071611de_CH
dc.identifier.doi10.21256/zhaw-30503-
dc.identifier.pmid38611890de_CH
zhaw.funding.euNode_CH
zhaw.issue7de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.start1611de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume29de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedPhytopharmaziede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

Files in This Item:
File Description SizeFormat 
2024_Vahekeni-etal_Antiprotozoal-activity-plants-sickness_molecules.pdf1.95 MBAdobe PDFThumbnail
View/Open
Show simple item record
Vahekeni, N., Brillatz, T., Rahmaty, M., Cal, M., Keller-Maerki, S., Rocchetti, R., Kaiser, M., Sax, S., Mattli, K., Wolfram, E., Marcourt, L., Queiroz, E. F., Wolfender, J.-L., & Mäser, P. (2024). Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. active against T. b. rhodesiense. Molecules, 29(7), 1611. https://doi.org/10.3390/molecules29071611
Vahekeni, N. et al. (2024) ‘Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. active against T. b. rhodesiense’, Molecules, 29(7), p. 1611. Available at: https://doi.org/10.3390/molecules29071611.
N. Vahekeni et al., “Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. active against T. b. rhodesiense,” Molecules, vol. 29, no. 7, p. 1611, Apr. 2024, doi: 10.3390/molecules29071611.
VAHEKENI, Nina, Théo BRILLATZ, Marjan RAHMATY, Monica CAL, Sonja KELLER-MAERKI, Romina ROCCHETTI, Marcel KAISER, Sibylle SAX, Kevin MATTLI, Evelyn WOLFRAM, Laurence MARCOURT, Emerson Ferreira QUEIROZ, Jean-Luc WOLFENDER und Pascal MÄSER, 2024. Antiprotozoal activity of plants used in the management of sleeping sickness in Angola and bioactivity-guided fractionation of Brasenia schreberi J.F.Gmel and Nymphaea lotus L. active against T. b. rhodesiense. Molecules. 3 April 2024. Bd. 29, Nr. 7, S. 1611. DOI 10.3390/molecules29071611
Vahekeni, Nina, Théo Brillatz, Marjan Rahmaty, Monica Cal, Sonja Keller-Maerki, Romina Rocchetti, Marcel Kaiser, et al. 2024. “Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation of Brasenia Schreberi J.F.Gmel and Nymphaea Lotus L. Active against T. B. Rhodesiense.” Molecules 29 (7): 1611. https://doi.org/10.3390/molecules29071611.
Vahekeni, Nina, et al. “Antiprotozoal Activity of Plants Used in the Management of Sleeping Sickness in Angola and Bioactivity-Guided Fractionation of Brasenia Schreberi J.F.Gmel and Nymphaea Lotus L. Active against T. B. Rhodesiense.” Molecules, vol. 29, no. 7, Apr. 2024, p. 1611, https://doi.org/10.3390/molecules29071611.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.