Adaptive changes in sensorimotor processing in patients with acute low back pain

Boendermaker, Bart; Buechler, Roman; Michels, Lars; Nijs, Jo; Coppieters, Iris; Hotz-Boendermaker, Sabina

doi:10.1038/s41598-022-26174-2

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-30204

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Adaptive changes in sensorimotor processing in patients with acute low back pain
Authors:	Boendermaker, Bart Buechler, Roman Michels, Lars Nijs, Jo Coppieters, Iris Hotz-Boendermaker, Sabina
et. al:	No
DOI:	10.1038/s41598-022-26174-2 10.21256/zhaw-30204
Published in:	Scientific Reports
Volume(Issue):	12
Issue:	1
Page(s):	21741
Issue Date:	16-Dec-2022
Publisher / Ed. Institution:	Nature Publishing Group
ISSN:	2045-2322
Language:	English
Subjects:	Adult; Humans; Pain measurement; Magnetic resonance imaging; Lumbosacral region; Low back pain; Acute pain
Subject (DDC):	617.5: Orthopaedic surgery
Abstract:	In low back pain (LBP), primary care and secondary prevention of recurrent and persistent LBP are not always successful. Enhanced understanding of neural mechanisms of sensorimotor processing and pain modulation in patients with acute LBP is mandatory. This explorative fMRI study investigated sensorimotor processing due to mechanosensory stimulation of the lumbar spine. We studied 19 adult patients with acute LBP (< 4 weeks of an acute episode) and 23 healthy controls. On a numeric rating scale, patients reported moderate mean pain intensity of 4.5 out of 10, while LBP-associated disability indicated mild mean disability. The event-related fMRI analysis yielded no between-group differences. However, the computation of functional connectivity resulted in adaptive changes in networks involved in sensorimotor processing in the patient group: Connectivity strength was decreased in the salience and cerebellar networks but increased in the limbic and parahippocampal networks. Timewise, these results indicate that early connectivity changes might reflect adaptive physiological processes in an episode of acute LBP. These findings raise intriguing questions regarding their role in pain persistence and recurrences of LBP, particularly concerning the multiple consequences of acute LBP pain. Advanced understanding of neural mechanisms of processing non-painful mechanosensations in LBP may also improve therapeutic approaches.
URI:	https://digitalcollection.zhaw.ch/handle/11475/30204
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	School of Health Sciences
Organisational Unit:	Institute of Physiotherapy (IPT)
Published as part of the ZHAW project:	Bi-directional interactions of sensory perception, motor performance and fear of movement in the development of persistent low back pain
Appears in collections:	Publikationen Gesundheit

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Boendermaker, B., Buechler, R., Michels, L., Nijs, J., Coppieters, I., & Hotz-Boendermaker, S. (2022). Adaptive changes in sensorimotor processing in patients with acute low back pain. Scientific Reports, 12(1), 21741. https://doi.org/10.1038/s41598-022-26174-2

Boendermaker, B. et al. (2022) ‘Adaptive changes in sensorimotor processing in patients with acute low back pain’, Scientific Reports, 12(1), p. 21741. Available at: https://doi.org/10.1038/s41598-022-26174-2.

B. Boendermaker, R. Buechler, L. Michels, J. Nijs, I. Coppieters, and S. Hotz-Boendermaker, “Adaptive changes in sensorimotor processing in patients with acute low back pain,” Scientific Reports, vol. 12, no. 1, p. 21741, Dec. 2022, doi: 10.1038/s41598-022-26174-2.

BOENDERMAKER, Bart, Roman BUECHLER, Lars MICHELS, Jo NIJS, Iris COPPIETERS und Sabina HOTZ-BOENDERMAKER, 2022. Adaptive changes in sensorimotor processing in patients with acute low back pain. Scientific Reports. 16 Dezember 2022. Bd. 12, Nr. 1, S. 21741. DOI 10.1038/s41598-022-26174-2

Boendermaker, Bart, Roman Buechler, Lars Michels, Jo Nijs, Iris Coppieters, and Sabina Hotz-Boendermaker. 2022. “Adaptive Changes in Sensorimotor Processing in Patients with Acute Low Back Pain.” Scientific Reports 12 (1): 21741. https://doi.org/10.1038/s41598-022-26174-2.

Boendermaker, Bart, et al. “Adaptive Changes in Sensorimotor Processing in Patients with Acute Low Back Pain.” Scientific Reports, vol. 12, no. 1, Dec. 2022, p. 21741, https://doi.org/10.1038/s41598-022-26174-2.