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https://doi.org/10.21256/zhaw-1692Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Fischer, Thomas | - |
| dc.contributor.author | Riedl, Rainer | - |
| dc.date.accessioned | 2018-02-20T16:16:50Z | - |
| dc.date.available | 2018-02-20T16:16:50Z | - |
| dc.date.issued | 2017 | - |
| dc.identifier.issn | 1420-3049 | de_CH |
| dc.identifier.issn | 1433-1373 | de_CH |
| dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/2895 | - |
| dc.description.abstract | Matrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extracellular matrix proteins such as casein, gelatin, fibronectin and proteoglycan. MMP-7 is a validated target for the development of small molecule drugs against cancer. MMP-13 is within the enzyme class the most efficient contributor to type II collagen degeneration and is a validated target in arthritis and cancer. We have developed the dual MMP-7/-13 inhibitor ZHAWOC6941 with IC50-values of 2.2 M (MMP-7) and 1.2 M (MMP-13) that is selective over a broad range of MMP isoforms. It spares MMP-1, -2, -3, -8, -9, -12 and -14, making it a valuable modulator for targeted polypharmacology approaches. | de_CH |
| dc.language.iso | en | de_CH |
| dc.publisher | MDPI | de_CH |
| dc.relation.ispartof | Molecules | de_CH |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | de_CH |
| dc.subject | Medicinal chemistry | de_CH |
| dc.subject | Drug discovery | de_CH |
| dc.subject | Inhibitor | de_CH |
| dc.subject.ddc | 615: Pharmakologie und Therapeutik | de_CH |
| dc.title | Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor | de_CH |
| dc.type | Beitrag in wissenschaftlicher Zeitschrift | de_CH |
| dcterms.type | Text | de_CH |
| zhaw.departement | Life Sciences und Facility Management | de_CH |
| dc.identifier.doi | 10.3390/molecules22091548 | de_CH |
| dc.identifier.doi | 10.21256/zhaw-1692 | - |
| zhaw.funding.eu | No | de_CH |
| zhaw.issue | 9 | de_CH |
| zhaw.originated.zhaw | Yes | de_CH |
| zhaw.publication.status | publishedVersion | de_CH |
| zhaw.volume | 22 | de_CH |
| zhaw.publication.review | Peer review (Publikation) | de_CH |
| zhaw.webfeed | CC Drug Discovery | de_CH |
| Appears in collections: | Publikationen Life Sciences und Facility Management | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2017_Fischer_Development of a non-hydroxamate dual matrix metalloproteinase_Molecules.pdf | 1.83 MB | Adobe PDF |  View/Open |
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Fischer, T., & Riedl, R. (2017). Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor. Molecules, 22(9). https://doi.org/10.3390/molecules22091548
Fischer, T. and Riedl, R. (2017) ‘Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor’, Molecules, 22(9). Available at: https://doi.org/10.3390/molecules22091548.
T. Fischer and R. Riedl, “Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor,” Molecules, vol. 22, no. 9, 2017, doi: 10.3390/molecules22091548.
FISCHER, Thomas und Rainer RIEDL, 2017. Development of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitor. Molecules. 2017. Bd. 22, Nr. 9. DOI 10.3390/molecules22091548
Fischer, Thomas, and Rainer Riedl. 2017. “Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor.” Molecules 22 (9). https://doi.org/10.3390/molecules22091548.
Fischer, Thomas, and Rainer Riedl. “Development of a Non-Hydroxamate Dual Matrix Metalloproteinase (MMP)-7/-13 Inhibitor.” Molecules, vol. 22, no. 9, 2017, https://doi.org/10.3390/molecules22091548.
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