Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-1692
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dc.contributor.authorFischer, Thomas-
dc.contributor.authorRiedl, Rainer-
dc.date.accessioned2018-02-20T16:16:50Z-
dc.date.available2018-02-20T16:16:50Z-
dc.date.issued2017-
dc.identifier.issn1420-3049de_CH
dc.identifier.issn1433-1373de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2895-
dc.description.abstractMatrix metalloproteinase 7 (MMP-7) is a member of the MMP superfamily and is able to degrade extracellular matrix proteins such as casein, gelatin, fibronectin and proteoglycan. MMP-7 is a validated target for the development of small molecule drugs against cancer. MMP-13 is within the enzyme class the most efficient contributor to type II collagen degeneration and is a validated target in arthritis and cancer. We have developed the dual MMP-7/-13 inhibitor ZHAWOC6941 with IC50-values of 2.2 M (MMP-7) and 1.2 M (MMP-13) that is selective over a broad range of MMP isoforms. It spares MMP-1, -2, -3, -8, -9, -12 and -14, making it a valuable modulator for targeted polypharmacology approaches.de_CH
dc.language.isoende_CH
dc.publisherMDPIde_CH
dc.relation.ispartofMoleculesde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectMedicinal chemistryde_CH
dc.subjectDrug discoveryde_CH
dc.subjectInhibitorde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleDevelopment of a non-hydroxamate dual matrix metalloproteinase (MMP)-7/-13 inhibitorde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
dc.identifier.doi10.21256/zhaw-1692-
dc.identifier.doi10.3390/molecules22091548de_CH
zhaw.funding.euNode_CH
zhaw.issue9de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume22de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in Collections:Publikationen Life Sciences und Facility Management

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