Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-28950Full metadata record
| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Koch, Franziska | - |
| dc.contributor.author | Müller, Michael | - |
| dc.contributor.author | König, Finja | - |
| dc.contributor.author | Meyer, Nina | - |
| dc.contributor.author | Gattlen, Jasmin | - |
| dc.contributor.author | Pieles, Uwe | - |
| dc.contributor.author | Peters, Kirsten | - |
| dc.contributor.author | Kreikemeyer, Bernd | - |
| dc.contributor.author | Mathes, Stephanie | - |
| dc.contributor.author | Saxer, Sina | - |
| dc.date.accessioned | 2023-10-21T13:55:54Z | - |
| dc.date.available | 2023-10-21T13:55:54Z | - |
| dc.date.issued | 2018 | - |
| dc.identifier.issn | 2054-5703 | de_CH |
| dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/28950 | - |
| dc.description.abstract | Self-assembling peptide hydrogels can be modified regarding their biodegradability, their chemical and mechanical properties and their nanofibrillar structure. Thus, self-assembling peptide hydrogels might be suitable scaffolds for regenerative therapies and tissue engineering. Owing to the use of various peptide concentrations and buffer compositions, the self-assembling peptide hydrogels might be influenced regarding their mechanical characteristics. Therefore, the mechanical properties and stability of a set of self-assembling peptide hydrogels, consisting of 11 amino acids, made from four beta sheet self-assembling peptides in various peptide concentrations and buffer compositions were studied. The formed self-assembling peptide hydrogels exhibited stiffnesses ranging from 0.6 to 205 kPa. The hydrogel stiffness was mostly affected by peptide sequence followed by peptide concentration and buffer composition. All self-assembling peptide hydrogels examined provided a nanofibrillar network formation. A maximum self-assembling peptide hydrogel dissolution of 20% was observed for different buffer solutions after 7 days. The stability regarding enzymatic and bacterial digestion showed less degradation in comparison to the self-assembling peptide hydrogel dissolution rate in buffer. The tested set of self-assembling peptide hydrogels were able to form stable scaffolds and provided a broad spectrum of tissue-specific stiffnesses that are suitable for a regenerative therapy. | de_CH |
| dc.language.iso | en | de_CH |
| dc.publisher | The Royal Society Publishing | de_CH |
| dc.relation.ispartof | Royal Society Open Science | de_CH |
| dc.rights | http://creativecommons.org/licenses/by/4.0/ | de_CH |
| dc.subject | SAP hydrogel degradability | de_CH |
| dc.subject | SAP hydrogel stiffness | de_CH |
| dc.subject | Nanofibrillar architecture | de_CH |
| dc.subject | Self-assembling peptides (SAP) | de_CH |
| dc.subject.ddc | 660: Technische Chemie | de_CH |
| dc.title | Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition | de_CH |
| dc.type | Beitrag in wissenschaftlicher Zeitschrift | de_CH |
| dcterms.type | Text | de_CH |
| zhaw.departement | Life Sciences und Facility Management | de_CH |
| dc.identifier.doi | 10.1098/rsos.171562 | de_CH |
| dc.identifier.doi | 10.21256/zhaw-28950 | - |
| dc.identifier.pmid | 29657766 | de_CH |
| zhaw.funding.eu | No | de_CH |
| zhaw.issue | 3 | de_CH |
| zhaw.originated.zhaw | Yes | de_CH |
| zhaw.pages.start | 171562 | de_CH |
| zhaw.publication.status | publishedVersion | de_CH |
| zhaw.volume | 5 | de_CH |
| zhaw.publication.review | Peer review (Publikation) | de_CH |
| zhaw.author.additional | No | de_CH |
| zhaw.display.portrait | Yes | de_CH |
| Appears in collections: | Publikationen Life Sciences und Facility Management | |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 2018_Koch-etal_Mechanical-characteristics-of-beta-sheetforming-peptide-hydrogels_RoyalSociety.pdf | 1.11 MB | Adobe PDF |  View/Open |
Show simple item record
Koch, F., Müller, M., König, F., Meyer, N., Gattlen, J., Pieles, U., Peters, K., Kreikemeyer, B., Mathes, S., & Saxer, S. (2018). Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition. Royal Society Open Science, 5(3), 171562. https://doi.org/10.1098/rsos.171562
Koch, F. et al. (2018) ‘Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition’, Royal Society Open Science, 5(3), p. 171562. Available at: https://doi.org/10.1098/rsos.171562.
F. Koch et al., “Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition,” Royal Society Open Science, vol. 5, no. 3, p. 171562, 2018, doi: 10.1098/rsos.171562.
KOCH, Franziska, Michael MÜLLER, Finja KÖNIG, Nina MEYER, Jasmin GATTLEN, Uwe PIELES, Kirsten PETERS, Bernd KREIKEMEYER, Stephanie MATHES und Sina SAXER, 2018. Mechanical characteristics of beta sheet-forming peptide hydrogels are dependent on peptide sequence, concentration and buffer composition. Royal Society Open Science. 2018. Bd. 5, Nr. 3, S. 171562. DOI 10.1098/rsos.171562
Koch, Franziska, Michael Müller, Finja König, Nina Meyer, Jasmin Gattlen, Uwe Pieles, Kirsten Peters, Bernd Kreikemeyer, Stephanie Mathes, and Sina Saxer. 2018. “Mechanical Characteristics of Beta Sheet-Forming Peptide Hydrogels Are Dependent on Peptide Sequence, Concentration and Buffer Composition.” Royal Society Open Science 5 (3): 171562. https://doi.org/10.1098/rsos.171562.
Koch, Franziska, et al. “Mechanical Characteristics of Beta Sheet-Forming Peptide Hydrogels Are Dependent on Peptide Sequence, Concentration and Buffer Composition.” Royal Society Open Science, vol. 5, no. 3, 2018, p. 171562, https://doi.org/10.1098/rsos.171562.
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