Maintenance therapy with antidepressants : prophylactic effects or withdrawal reactions?

Plöderl, Martin; Hengartner, Michael P.

Publication type:	Research data
Title:	Maintenance therapy with antidepressants : prophylactic effects or withdrawal reactions?
Authors:	Plöderl, Martin Hengartner, Michael P.
et. al:	No
Issue Date:	2021
Publisher / Ed. Institution:	OSF
Language:	English
Subject (DDC):	615: Pharmacology and therapeutics 616.8: Neurology, diseases of nervous system
Abstract:	Relapse prevention trials build the scientific foundation for recommendation of antidepressant continuation and maintenance therapy. However, the validity of the evidence is disputed and may be biased due to withdrawal confounding. We digitised and analysed the survival curves (time-to-event data) from all antidepressant relapse prevention trials submitted to the US Food and Drug Administration between 1987 and 2012. The main outcome was the percentage of the drug effect (antidepressant-placebo difference in relapse events) at any week of the maintenance phase in relation to the total drug effect at the end of the randomised maintenance phase.
URI:	https://osf.io/btm5p/ https://digitalcollection.zhaw.ch/handle/11475/28487
Related publications:	https://doi.org/10.1177/20451253211032051
License (according to publishing contract):	Licence according to publishing contract
Departement:	Applied Psychology
Organisational Unit:	Psychological Institute (PI)
Appears in collections:	ZHAW Forschungsdaten Angewandte Psychologie

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Plöderl, M., & Hengartner, M. P. (2021). Maintenance therapy with antidepressants : prophylactic effects or withdrawal reactions? [Data set]. OSF. https://osf.io/btm5p/

Plöderl, M. and Hengartner, M.P. (2021) ‘Maintenance therapy with antidepressants : prophylactic effects or withdrawal reactions?’ OSF. Available at: https://osf.io/btm5p/.

M. Plöderl and M. P. Hengartner, “Maintenance therapy with antidepressants : prophylactic effects or withdrawal reactions?” OSF, 2021. [Online]. Available: https://osf.io/btm5p/

PLÖDERL, Martin und Michael P. HENGARTNER, 2021. Maintenance therapy with antidepressants : prophylactic effects or withdrawal reactions? [online]. Data set. 2021. OSF. Verfügbar unter: https://osf.io/btm5p/

Plöderl, Martin, and Michael P. Hengartner. 2021. “Maintenance Therapy with Antidepressants : Prophylactic Effects or Withdrawal Reactions?” Data set. OSF. https://osf.io/btm5p/.

Plöderl, Martin, and Michael P. Hengartner. Maintenance Therapy with Antidepressants : Prophylactic Effects or Withdrawal Reactions? OSF, 2021, https://osf.io/btm5p/.