Prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN) with non-pharmacological interventions : clinical recommendations from a systematic scoping review and an expert consensus process

Klafke, Nadja; Bossert, Jasmin; Kröger, Birgit; Neuberger, Petra; Heyder, Ute; Layer, Monika; Winkler, Marcela; Idler, Christel; Kaschdailewitsch, Elke; Heine, Rolf; John, Heike; Zielke, Tatjana; Schmeling, Beeke; Joy, Sosamma; Mertens, Isabel; Babadag-Savas, Burcu; Kohler, Sara Kerstin; Mahler, Cornelia; Witt, Claudia M.; Steinmann, Diana; Voiss, Petra; Stolz, Regina

doi:10.3390/medsci11010015

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-27987

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN) with non-pharmacological interventions : clinical recommendations from a systematic scoping review and an expert consensus process
Authors:	Klafke, Nadja Bossert, Jasmin Kröger, Birgit Neuberger, Petra Heyder, Ute Layer, Monika Winkler, Marcela Idler, Christel Kaschdailewitsch, Elke Heine, Rolf John, Heike Zielke, Tatjana Schmeling, Beeke Joy, Sosamma Mertens, Isabel Babadag-Savas, Burcu Kohler, Sara Kerstin Mahler, Cornelia Witt, Claudia M. Steinmann, Diana Voiss, Petra Stolz, Regina
et. al:	No
DOI:	10.3390/medsci11010015 10.21256/zhaw-27987
Published in:	Medical Sciences
Volume(Issue):	11
Issue:	1
Page(s):	15
Issue Date:	30-Jan-2023
Publisher / Ed. Institution:	MDPI
ISSN:	2076-3271
Language:	English
Subjects:	Cancer; Chemotherapy-induced peripheral neuropathy (CIPN); Consensus process; Integrative oncology; Interprofessional healthcare; Non-pharmacological intervention; Scoping review; Supportive therapy; Human; Consensus; Antineoplastic agent; Peripheral nervous system disease; Neoplasm; Complementary therapy
Subject (DDC):	615: Pharmacology and therapeutics 616: Internal medicine and diseases
Abstract:	Background: Most individuals affected by cancer who are treated with certain chemotherapies suffer of CIPN. Therefore, there is a high patient and provider interest in complementary non-pharmacological therapies, but its evidence base has not yet been clearly pointed out in the context of CIPN. Methods: The results of a scoping review overviewing the published clinical evidence on the application of complementary therapies for improving the complex CIPN symptomatology are synthesized with the recommendations of an expert consensus process aiming to draw attention to supportive strategies for CIPN. The scoping review, registered at PROSPERO 2020 (CRD 42020165851), followed the PRISMA-ScR and JBI guidelines. Relevant studies published in Pubmed/MEDLINE, PsycINFO, PEDro, Cochrane CENTRAL, and CINAHL between 2000 and 2021 were included. CASP was used to evaluate the methodologic quality of the studies. Results: Seventy-five studies with mixed study quality met the inclusion criteria. Manipulative therapies (including massage, reflexology, therapeutic touch), rhythmical embrocations, movement and mind-body therapies, acupuncture/acupressure, and TENS/Scrambler therapy were the most frequently analyzed in research and may be effective treatment options for CIPN. The expert panel approved 17 supportive interventions, most of them were phytotherapeutic interventions including external applications and cryotherapy, hydrotherapy, and tactile stimulation. More than two-thirds of the consented interventions were rated with moderate to high perceived clinical effectiveness in therapeutic use. Conclusions: The evidence of both the review and the expert panel supports a variety of complementary procedures regarding the supportive treatment of CIPN; however, the application on patients should be individually weighed in each case. Based on this meta-synthesis, interprofessional healthcare teams may open up a dialogue with patients interested in non-pharmacological treatment options to tailor complementary counselling and treatments to their needs.
URI:	https://digitalcollection.zhaw.ch/handle/11475/27987
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	School of Health Sciences
Organisational Unit:	Institute of Nursing (IPF)
Appears in collections:	Publikationen Gesundheit

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Klafke, N., Bossert, J., Kröger, B., Neuberger, P., Heyder, U., Layer, M., Winkler, M., Idler, C., Kaschdailewitsch, E., Heine, R., John, H., Zielke, T., Schmeling, B., Joy, S., Mertens, I., Babadag-Savas, B., Kohler, S. K., Mahler, C., Witt, C. M., et al. (2023). Prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN) with non-pharmacological interventions : clinical recommendations from a systematic scoping review and an expert consensus process. Medical Sciences, 11(1), 15. https://doi.org/10.3390/medsci11010015

Klafke, N. et al. (2023) ‘Prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN) with non-pharmacological interventions : clinical recommendations from a systematic scoping review and an expert consensus process’, Medical Sciences, 11(1), p. 15. Available at: https://doi.org/10.3390/medsci11010015.

N. Klafke et al., “Prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN) with non-pharmacological interventions : clinical recommendations from a systematic scoping review and an expert consensus process,” Medical Sciences, vol. 11, no. 1, p. 15, Jan. 2023, doi: 10.3390/medsci11010015.

KLAFKE, Nadja, Jasmin BOSSERT, Birgit KRÖGER, Petra NEUBERGER, Ute HEYDER, Monika LAYER, Marcela WINKLER, Christel IDLER, Elke KASCHDAILEWITSCH, Rolf HEINE, Heike JOHN, Tatjana ZIELKE, Beeke SCHMELING, Sosamma JOY, Isabel MERTENS, Burcu BABADAG-SAVAS, Sara Kerstin KOHLER, Cornelia MAHLER, Claudia M. WITT, Diana STEINMANN, Petra VOISS und Regina STOLZ, 2023. Prevention and treatment of chemotherapy-induced peripheral neuropathy (CIPN) with non-pharmacological interventions : clinical recommendations from a systematic scoping review and an expert consensus process. Medical Sciences. 30 Januar 2023. Bd. 11, Nr. 1, S. 15. DOI 10.3390/medsci11010015

Klafke, Nadja, Jasmin Bossert, Birgit Kröger, Petra Neuberger, Ute Heyder, Monika Layer, Marcela Winkler, et al. 2023. “Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy (CIPN) with Non-Pharmacological Interventions : Clinical Recommendations from a Systematic Scoping Review and an Expert Consensus Process.” Medical Sciences 11 (1): 15. https://doi.org/10.3390/medsci11010015.

Klafke, Nadja, et al. “Prevention and Treatment of Chemotherapy-Induced Peripheral Neuropathy (CIPN) with Non-Pharmacological Interventions : Clinical Recommendations from a Systematic Scoping Review and an Expert Consensus Process.” Medical Sciences, vol. 11, no. 1, Jan. 2023, p. 15, https://doi.org/10.3390/medsci11010015.