Please use this identifier to cite or link to this item:
https://doi.org/10.21256/zhaw-27765
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Koch, Franziska | - |
dc.contributor.author | Wolff, Anne | - |
dc.contributor.author | Mathes, Stephanie | - |
dc.contributor.author | Pieles, Uwe | - |
dc.contributor.author | Saxer, Sina S. | - |
dc.contributor.author | Kreikemeyer, Bernd | - |
dc.contributor.author | Peters, Kirsten | - |
dc.date.accessioned | 2023-04-28T13:17:07Z | - |
dc.date.available | 2023-04-28T13:17:07Z | - |
dc.date.issued | 2018 | - |
dc.identifier.issn | 1176-9114 | de_CH |
dc.identifier.issn | 1178-2013 | de_CH |
dc.identifier.uri | https://digitalcollection.zhaw.ch/handle/11475/27765 | - |
dc.description.abstract | Background: The regeneration of tissue defects at the interface between soft and hard tissue, eg, in the periodontium, poses a challenge due to the divergent tissue requirements. A class of biomaterials that may support the regeneration at the soft-to-hard tissue interface are self-assembling peptides (SAPs), as their physicochemical and mechanical properties can be rationally designed to meet tissue requirements. Materials and methods: In this work, we investigated the effect of two single-component and two complementary β-sheet forming SAP systems on their hydrogel properties such as nanofibrillar architecture, surface charge, and protein adsorption as well as their influence on cell adhesion, morphology, growth, and differentiation. Results: We showed that these four 11-amino acid SAP (P11-SAP) hydrogels possessed physicochemical characteristics dependent on their amino acid composition that allowed variabilities in nanofibrillar network architecture, surface charge, and protein adsorption (eg, the single-component systems demonstrated an ~30% higher porosity and an almost 2-fold higher protein adsorption compared with the complementary systems). Cytocompatibility studies revealed similar results for cells cultured on the four P11-SAP hydrogels compared with cells on standard cell culture surfaces. The single-component P11-SAP systems showed a 1.7-fold increase in cell adhesion and cellular growth compared with the complementary P11-SAP systems. Moreover, significantly enhanced osteogenic differentiation of human calvarial osteoblasts was detected for the single-component P11-SAP system hydrogels compared with standard cell cultures. Conclusion: Thus, single-component system P11-SAP hydrogels can be assessed as suitable scaffolds for periodontal regeneration therapy, as they provide adjustable, extracellular matrix-mimetic nanofibrillar architecture and favorable cellular interaction with periodontal cells. | de_CH |
dc.language.iso | en | de_CH |
dc.publisher | Dove Medical Press | de_CH |
dc.relation.ispartof | International Journal of Nanomedicine | de_CH |
dc.rights | https://creativecommons.org/licenses/by-nc/3.0/ | de_CH |
dc.subject | P11-SAP hydrogel | de_CH |
dc.subject | SAP | de_CH |
dc.subject | Cell proliferation | de_CH |
dc.subject | Osteogenic differentiation | de_CH |
dc.subject | periodontal tissue regeneration | de_CH |
dc.subject | Protein adsorption | de_CH |
dc.subject | Self-assembling peptide | de_CH |
dc.subject | Surface charge | de_CH |
dc.subject | Amino acid | de_CH |
dc.subject | Cell adhesion | de_CH |
dc.subject | Cell differentiation | de_CH |
dc.subject | Cells, cultured | de_CH |
dc.subject | Extracellular matrix | de_CH |
dc.subject | Human | de_CH |
dc.subject | Hydrogel | de_CH |
dc.subject | In vitro technique | de_CH |
dc.subject | Nanofiber | de_CH |
dc.subject | Neural stem cell | de_CH |
dc.subject | Osteoblast | de_CH |
dc.subject | Peptide fragment | de_CH |
dc.subject | Periodontium | de_CH |
dc.subject | Osteogenesis | de_CH |
dc.subject.ddc | 610.28: Biomedizin, Biomedizinische Technik | de_CH |
dc.title | Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro | de_CH |
dc.type | Beitrag in wissenschaftlicher Zeitschrift | de_CH |
dcterms.type | Text | de_CH |
zhaw.departement | Life Sciences und Facility Management | de_CH |
zhaw.organisationalunit | Institut für Chemie und Biotechnologie (ICBT) | de_CH |
dc.identifier.doi | 10.2147/IJN.S173702 | de_CH |
dc.identifier.doi | 10.21256/zhaw-27765 | - |
dc.identifier.pmid | 30425485 | de_CH |
zhaw.funding.eu | No | de_CH |
zhaw.originated.zhaw | Yes | de_CH |
zhaw.pages.end | 6733 | de_CH |
zhaw.pages.start | 6717 | de_CH |
zhaw.publication.status | publishedVersion | de_CH |
zhaw.volume | 13 | de_CH |
zhaw.publication.review | Peer review (Publikation) | de_CH |
zhaw.author.additional | No | de_CH |
zhaw.display.portrait | Yes | de_CH |
Appears in collections: | Publikationen Life Sciences und Facility Management |
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File | Description | Size | Format | |
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2018_Koch-etal_Amino-acid-composition-of-nanofibrillar-self-assembling-peptide.pdf | 3.63 MB | Adobe PDF | View/Open |
Show simple item record
Koch, F., Wolff, A., Mathes, S., Pieles, U., Saxer, S. S., Kreikemeyer, B., & Peters, K. (2018). Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro. International Journal of Nanomedicine, 13, 6717–6733. https://doi.org/10.2147/IJN.S173702
Koch, F. et al. (2018) ‘Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro’, International Journal of Nanomedicine, 13, pp. 6717–6733. Available at: https://doi.org/10.2147/IJN.S173702.
F. Koch et al., “Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro,” International Journal of Nanomedicine, vol. 13, pp. 6717–6733, 2018, doi: 10.2147/IJN.S173702.
KOCH, Franziska, Anne WOLFF, Stephanie MATHES, Uwe PIELES, Sina S. SAXER, Bernd KREIKEMEYER und Kirsten PETERS, 2018. Amino acid composition of nanofibrillar self-assembling peptide hydrogels affects responses of periodontal tissue cells in vitro. International Journal of Nanomedicine. 2018. Bd. 13, S. 6717–6733. DOI 10.2147/IJN.S173702
Koch, Franziska, Anne Wolff, Stephanie Mathes, Uwe Pieles, Sina S. Saxer, Bernd Kreikemeyer, and Kirsten Peters. 2018. “Amino Acid Composition of Nanofibrillar Self-Assembling Peptide Hydrogels Affects Responses of Periodontal Tissue Cells in Vitro.” International Journal of Nanomedicine 13: 6717–33. https://doi.org/10.2147/IJN.S173702.
Koch, Franziska, et al. “Amino Acid Composition of Nanofibrillar Self-Assembling Peptide Hydrogels Affects Responses of Periodontal Tissue Cells in Vitro.” International Journal of Nanomedicine, vol. 13, 2018, pp. 6717–33, https://doi.org/10.2147/IJN.S173702.
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