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dc.contributor.authorAdlhart, Christian-
dc.contributor.authorVerran, Joanna-
dc.contributor.authorAzevedo, Nuno F.-
dc.contributor.authorOlmez, Hulya-
dc.contributor.authorKeinänen-Toivola, Minna M.-
dc.contributor.authorGouveia, Isabel-
dc.contributor.authorMelo, Luis F.-
dc.contributor.authorCrijns, Francy-
dc.description.abstractThe spread of infections in health care environments is a persistent and growing problem in most countries, aggravated by the development of microbial resistance to antibiotics and disinfectants. In addition to indwelling medical devices (implants, catheters, etc.), such infections may also result from adhesion of microbes either to external solid-water interfaces such as shower caps, taps, drains, etc, or to external solid-gas interfaces such as door handles, clothes, curtains, computer keyboards, etc. The latter are the main focus of the present work, where an overview of antimicrobial coatings for such applications is presented. The paper addresses well-established and novel methodologies, including chemical and physical functional modification of surfaces to reduce microbial contamination, as well as the potential risks associated to the implementation of such anti-contamination measures. Different chemistry-based approaches are discussed, in particular anti-adhesive surfaces (e.g., superhydrophobic, zwitterions, etc.) contact-killing surfaces (e.g., polymer brushes, phages, etc.) and biocide-releasing surfaces (e.g., triggered release, quorum sensing-based systems, etc.). The paper also assesses the impact of topographical modifications at distinct dimensions (micrometre and nanometre orders of magnitude) and the importance of applying safe-by-design criteria (toxicity, contribution for unwanted acquisition of antimicrobial resistance, long-term stability, etc.) when developing and implementing antimicrobial surfaces.de_CH
dc.relation.ispartofJournal of Hospital Infectionde_CH
dc.subjectHealthcare contaminationde_CH
dc.subjectAntimicrobial coatingsde_CH
dc.subjectSafe by designde_CH
dc.subject.ddc540: Chemiede_CH
dc.subject.ddc620: Ingenieurwesende_CH
dc.titleSurface modifications for antimicrobial effects in the healthcare setting : a critical overviewde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
Appears in Collections:Publikationen Life Sciences und Facility Management

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