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Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-26902
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dc.contributor.authorKiss, Cedric-
dc.contributor.authorGall, Flavio M.-
dc.contributor.authorDreier, Birgit-
dc.contributor.authorAdams, Michael-
dc.contributor.authorRiedl, Rainer-
dc.contributor.authorPlückthun, Andreas-
dc.contributor.authorMittl, Peer R. E.-
dc.date.accessioned2023-02-11T09:33:15Z-
dc.date.available2023-02-11T09:33:15Z-
dc.date.issued2022-12-01-
dc.identifier.issn2059-7983de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26902-
dc.description.abstractPeptides comprising many hydrophobic amino acids are almost insoluble under physiological buffer conditions, which complicates their structural analysis. To investigate the three-dimensional structure of the hydrophobic leucinostatin derivative ZHAWOC6027, the previously developed host lattice display technology was applied. Two designed ankyrin-repeat proteins (DARPins) recognizing a biotinylated ZHAWOC6027 derivative were selected from a diverse library by ribosome display under aqueous buffer conditions. ZHAWOC6027 was immobilized by means of the DARPin in the host lattice and the structure of the complex was determined by X-ray diffraction. ZHAWOC6027 adopts a distorted α-helical conformation. Comparison with the structures of related compounds that have been determined in organic solvents reveals elevated flexibility of the termini, which might be functionally important.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofActa Crystallographica. Section D: Structural Biologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectCrystal engineeringde_CH
dc.subjectHost lattice displayde_CH
dc.subjectLeucinostatinde_CH
dc.subjectRibosomede_CH
dc.subjectX-ray diffractionde_CH
dc.subjectAntimicrobial cationic peptidede_CH
dc.subjectAmino acidde_CH
dc.subject.ddc572: Biochemiede_CH
dc.titleStructure of a hydrophobic leucinostatin derivative determined by host lattice displayde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1107/S2059798322010762de_CH
dc.identifier.doi10.21256/zhaw-26902-
dc.identifier.pmid36458615de_CH
zhaw.funding.euNode_CH
zhaw.issue12de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end1450de_CH
zhaw.pages.start1439de_CH
zhaw.publication.statusacceptedVersionde_CH
zhaw.volume78de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedOrganische Chemiede_CH
zhaw.webfeedCC Drug Discoveryde_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Kiss, C., Gall, F. M., Dreier, B., Adams, M., Riedl, R., Plückthun, A., & Mittl, P. R. E. (2022). Structure of a hydrophobic leucinostatin derivative determined by host lattice display. Acta Crystallographica. Section D: Structural Biology, 78(12), 1439–1450. https://doi.org/10.1107/S2059798322010762
Kiss, C. et al. (2022) ‘Structure of a hydrophobic leucinostatin derivative determined by host lattice display’, Acta Crystallographica. Section D: Structural Biology, 78(12), pp. 1439–1450. Available at: https://doi.org/10.1107/S2059798322010762.
C. Kiss et al., “Structure of a hydrophobic leucinostatin derivative determined by host lattice display,” Acta Crystallographica. Section D: Structural Biology, vol. 78, no. 12, pp. 1439–1450, Dec. 2022, doi: 10.1107/S2059798322010762.
KISS, Cedric, Flavio M. GALL, Birgit DREIER, Michael ADAMS, Rainer RIEDL, Andreas PLÜCKTHUN und Peer R. E. MITTL, 2022. Structure of a hydrophobic leucinostatin derivative determined by host lattice display. Acta Crystallographica. Section D: Structural Biology. 1 Dezember 2022. Bd. 78, Nr. 12, S. 1439–1450. DOI 10.1107/S2059798322010762
Kiss, Cedric, Flavio M. Gall, Birgit Dreier, Michael Adams, Rainer Riedl, Andreas Plückthun, and Peer R. E. Mittl. 2022. “Structure of a Hydrophobic Leucinostatin Derivative Determined by Host Lattice Display.” Acta Crystallographica. Section D: Structural Biology 78 (12): 1439–50. https://doi.org/10.1107/S2059798322010762.
Kiss, Cedric, et al. “Structure of a Hydrophobic Leucinostatin Derivative Determined by Host Lattice Display.” Acta Crystallographica. Section D: Structural Biology, vol. 78, no. 12, Dec. 2022, pp. 1439–50, https://doi.org/10.1107/S2059798322010762.


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