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  2. School of Engineering
  3. Publikationen
  4. Publikationen School of Engineering
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dc.contributor.authorMarconato, Laura-
dc.contributor.authorWeyland, Mathias S.-
dc.contributor.authorTresch, Nina-
dc.contributor.authorRossi, Federica-
dc.contributor.authorLeone, Vito-
dc.contributor.authorRohrer Bley, Carla-
dc.date.accessioned2022-11-17T11:16:35Z-
dc.date.available2022-11-17T11:16:35Z-
dc.date.issued2020-09-
dc.identifier.issn1476-5810de_CH
dc.identifier.issn1476-5829de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/26089-
dc.description.abstractRecently, a multimodal approach to oral squamous cell carcinoma (SCC) in cats, combining medical treatment and accelerated radiation therapy, showed a substantial outcome improvement in a small pilot study. Herein we retrospectively review 51 cats with unresectable, histologically confirmed oral SCC and a complete initial staging work-up: cats in group A (n = 24) received medical anti-angiogenic treatment consisting of bleomycin, piroxicam and thalidomide, cats in group B (n = 27) received the anti-angiogenic treatment and concurrent accelerated hypofractionated radiation therapy with 48Gy delivered in 10 fractions. Overall median progression-free interval (PFI) was poor with 70 days (95% CI: 48;93). In the irradiated cats (group B), however, PFI was significantly longer with 179 days (95% CI: 58;301) days, vs 30 days (95% CI: 23;38) in medically only treated cats (P < .001). Overall median overall survival (OS) was 89 days (95% CI: 55;124), again significantly longer in the irradiated cats (group B) with 136 (95% CI: 40;233) vs 38 days (95% CI: 23;54) (P < .001). In 8 of the 27 (29.6%) cats in group B, however, severe toxicity (grade 3) occurred. Neither onset nor severity of toxicity could be associated with any of the tested variables, including anatomic site, tumour size, clinical stage and duration of neoadjuvant medical treatment. Given the potential severe acute effects and the impact on quality of life after chemo-radiotherapy, owners must be clearly informed about the risks of treatment. With the overall poor outcome and high occurrence of acute toxicity, we cannot recommend the use of this accelerated radiation protocol combined with anti-angiogenic therapy for oral SCC in cats.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofVeterinary and Comparative Oncologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectBleomycinde_CH
dc.subjectCatde_CH
dc.subjectFelinede_CH
dc.subjectMetronomicde_CH
dc.subjectOral tumourde_CH
dc.subjectRadiation therapyde_CH
dc.subjectSide effectde_CH
dc.subjectThalidomidede_CH
dc.subjectAnimalde_CH
dc.subjectAntineoplastic combined chemotherapy protocolde_CH
dc.subjectCat diseasede_CH
dc.subjectFemalede_CH
dc.subjectMalede_CH
dc.subjectMouth neoplasmde_CH
dc.subjectRadiotherapyde_CH
dc.subjectRetrospective studyde_CH
dc.subjectSquamous cell carcinoma of head and neckde_CH
dc.subjectTreatment outcomede_CH
dc.subjectRadiation dose hypofractionationde_CH
dc.subject.ddc616: Innere Medizin und Krankheitende_CH
dc.subject.ddc630: Landwirtschaftde_CH
dc.titleToxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatmentde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementSchool of Engineeringde_CH
zhaw.organisationalunitInstitut für Angewandte Mathematik und Physik (IAMP)de_CH
dc.identifier.doi10.1111/vco.12557de_CH
dc.identifier.pmid31756259de_CH
zhaw.funding.euNode_CH
zhaw.issue3de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end369de_CH
zhaw.pages.start362de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume18de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Marconato, L., Weyland, M. S., Tresch, N., Rossi, F., Leone, V., & Rohrer Bley, C. (2020). Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment. Veterinary and Comparative Oncology, 18(3), 362–369. https://doi.org/10.1111/vco.12557
Marconato, L. et al. (2020) ‘Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment’, Veterinary and Comparative Oncology, 18(3), pp. 362–369. Available at: https://doi.org/10.1111/vco.12557.
L. Marconato, M. S. Weyland, N. Tresch, F. Rossi, V. Leone, and C. Rohrer Bley, “Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment,” Veterinary and Comparative Oncology, vol. 18, no. 3, pp. 362–369, Sep. 2020, doi: 10.1111/vco.12557.
MARCONATO, Laura, Mathias S. WEYLAND, Nina TRESCH, Federica ROSSI, Vito LEONE und Carla ROHRER BLEY, 2020. Toxicity and outcome in cats with oral squamous cell carcinoma after accelerated hypofractionated radiotherapy and concurrent systemic treatment. Veterinary and Comparative Oncology. September 2020. Bd. 18, Nr. 3, S. 362–369. DOI 10.1111/vco.12557
Marconato, Laura, Mathias S. Weyland, Nina Tresch, Federica Rossi, Vito Leone, and Carla Rohrer Bley. 2020. “Toxicity and Outcome in Cats with Oral Squamous Cell Carcinoma after Accelerated Hypofractionated Radiotherapy and Concurrent Systemic Treatment.” Veterinary and Comparative Oncology 18 (3): 362–69. https://doi.org/10.1111/vco.12557.
Marconato, Laura, et al. “Toxicity and Outcome in Cats with Oral Squamous Cell Carcinoma after Accelerated Hypofractionated Radiotherapy and Concurrent Systemic Treatment.” Veterinary and Comparative Oncology, vol. 18, no. 3, Sept. 2020, pp. 362–69, https://doi.org/10.1111/vco.12557.


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