Outcome, demography and resource utilization in ICU patients with delirium and malignancy

Sieber, Mattia; Rudiger, Alain; Schüpbach, Reto; Krüger, Bernard; Schubert, Maria; Bettex, Dominique

doi:10.1038/s41598-021-98200-8

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-24022

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Outcome, demography and resource utilization in ICU patients with delirium and malignancy
Authors:	Sieber, Mattia Rudiger, Alain Schüpbach, Reto Krüger, Bernard Schubert, Maria Bettex, Dominique
et. al:	No
DOI:	10.1038/s41598-021-98200-8 10.21256/zhaw-24022
Published in:	Scientific Reports
Volume(Issue):	11
Issue:	18756
Issue Date:	2021
Publisher / Ed. Institution:	Nature Publishing Group
ISSN:	2045-2322
Language:	English
Subjects:	Aged; Delirium; Female; Hospital mortality; Human; Length of stay; Longitudinal study; Male; Middle aged; Neoplasm; Retrospective study; Inpatient; Intensive care unit
Subject (DDC):	616.8: Neurology, diseases of nervous system
Abstract:	Delirium in the general intensive care unit (ICU) population is common, associated with adverse outcomes and well studied. However, knowledge on delirium in the increasing number of ICU patients with malignancy is scarce. The aim was to assess the frequency of delirium and its impact on resource utilizations and outcomes in ICU patients with malignancy. This retrospective, single-center longitudinal cohort study included all patients with malignancy admitted to ICUs of a University Hospital during one year. Delirium was diagnosed by an Intensive Care Delirium Screening Checklist (ICDSC) score ≥ 4. Of 488 ICU patients with malignancy, 176/488 (36%) developed delirium. Delirious patients were older (66 [55-72] vs. 61 [51-69] years, p = 0.001), had higher SAPS II (41 [27-68] vs. 24 [17-32], p < 0.001) and more frequently sepsis (26/176 [15%] vs. 6/312 [1.9%], p < 0.001) and/or shock (30/176 [6.1%] vs. 6/312 [1.9%], p < 0.001). In multivariate analysis, delirium was independently associated with lower discharge home (OR [95% CI] 0.37 [0.24-0.57], p < 0.001), longer ICU (HR [95% CI] 0.30 [0.23-0.37], p < 0.001) and hospital length of stay (HR [95% CI] 0.62 [0.50-0.77], p < 0.001), longer mechanical ventilation (HR [95% CI] 0.40 [0.28-0.57], p < 0.001), higher ICU nursing workload (B [95% CI] 1.92 [1.67-2.21], p < 0.001) and ICU (B [95% CI] 2.08 [1.81-2.38], p < 0.001) and total costs (B [95% CI] 1.44 [1.30-1.60], p < 0.001). However, delirium was not independently associated with in-hospital mortality (OR [95% CI] 2.26 [0.93-5.54], p = 0.074). In conclusion, delirium was a frequent complication in ICU patients with malignancy independently associated with high resource utilizations, however, it was not independently associated with in-hospital mortality.
URI:	https://digitalcollection.zhaw.ch/handle/11475/24022
Fulltext version:	Published version
License (according to publishing contract):	CC BY 4.0: Attribution 4.0 International
Departement:	School of Health Sciences
Organisational Unit:	Institute of Nursing (IPF)
Appears in collections:	Publikationen Gesundheit

Files in This Item:

File	Description	Size	Format
2021_Sieber-etal_Outcome-ICU-delirium_SciRepNature.pdf		1.12 MB	Adobe PDF	View/Open

Show full item record

Sieber, M., Rudiger, A., Schüpbach, R., Krüger, B., Schubert, M., & Bettex, D. (2021). Outcome, demography and resource utilization in ICU patients with delirium and malignancy. Scientific Reports, 11(18756). https://doi.org/10.1038/s41598-021-98200-8

Sieber, M. et al. (2021) ‘Outcome, demography and resource utilization in ICU patients with delirium and malignancy’, Scientific Reports, 11(18756). Available at: https://doi.org/10.1038/s41598-021-98200-8.

M. Sieber, A. Rudiger, R. Schüpbach, B. Krüger, M. Schubert, and D. Bettex, “Outcome, demography and resource utilization in ICU patients with delirium and malignancy,” Scientific Reports, vol. 11, no. 18756, 2021, doi: 10.1038/s41598-021-98200-8.

SIEBER, Mattia, Alain RUDIGER, Reto SCHÜPBACH, Bernard KRÜGER, Maria SCHUBERT und Dominique BETTEX, 2021. Outcome, demography and resource utilization in ICU patients with delirium and malignancy. Scientific Reports. 2021. Bd. 11, Nr. 18756. DOI 10.1038/s41598-021-98200-8

Sieber, Mattia, Alain Rudiger, Reto Schüpbach, Bernard Krüger, Maria Schubert, and Dominique Bettex. 2021. “Outcome, Demography and Resource Utilization in ICU Patients with Delirium and Malignancy.” Scientific Reports 11 (18756). https://doi.org/10.1038/s41598-021-98200-8.

Sieber, Mattia, et al. “Outcome, Demography and Resource Utilization in ICU Patients with Delirium and Malignancy.” Scientific Reports, vol. 11, no. 18756, 2021, https://doi.org/10.1038/s41598-021-98200-8.