Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-24022
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dc.contributor.authorSieber, Mattia-
dc.contributor.authorRudiger, Alain-
dc.contributor.authorSchüpbach, Reto-
dc.contributor.authorKrüger, Bernard-
dc.contributor.authorSchubert, Maria-
dc.contributor.authorBettex, Dominique-
dc.date.accessioned2022-01-27T15:52:33Z-
dc.date.available2022-01-27T15:52:33Z-
dc.date.issued2021-
dc.identifier.issn2045-2322de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/24022-
dc.description.abstractDelirium in the general intensive care unit (ICU) population is common, associated with adverse outcomes and well studied. However, knowledge on delirium in the increasing number of ICU patients with malignancy is scarce. The aim was to assess the frequency of delirium and its impact on resource utilizations and outcomes in ICU patients with malignancy. This retrospective, single-center longitudinal cohort study included all patients with malignancy admitted to ICUs of a University Hospital during one year. Delirium was diagnosed by an Intensive Care Delirium Screening Checklist (ICDSC) score ≥ 4. Of 488 ICU patients with malignancy, 176/488 (36%) developed delirium. Delirious patients were older (66 [55-72] vs. 61 [51-69] years, p = 0.001), had higher SAPS II (41 [27-68] vs. 24 [17-32], p < 0.001) and more frequently sepsis (26/176 [15%] vs. 6/312 [1.9%], p < 0.001) and/or shock (30/176 [6.1%] vs. 6/312 [1.9%], p < 0.001). In multivariate analysis, delirium was independently associated with lower discharge home (OR [95% CI] 0.37 [0.24-0.57], p < 0.001), longer ICU (HR [95% CI] 0.30 [0.23-0.37], p < 0.001) and hospital length of stay (HR [95% CI] 0.62 [0.50-0.77], p < 0.001), longer mechanical ventilation (HR [95% CI] 0.40 [0.28-0.57], p < 0.001), higher ICU nursing workload (B [95% CI] 1.92 [1.67-2.21], p < 0.001) and ICU (B [95% CI] 2.08 [1.81-2.38], p < 0.001) and total costs (B [95% CI] 1.44 [1.30-1.60], p < 0.001). However, delirium was not independently associated with in-hospital mortality (OR [95% CI] 2.26 [0.93-5.54], p = 0.074). In conclusion, delirium was a frequent complication in ICU patients with malignancy independently associated with high resource utilizations, however, it was not independently associated with in-hospital mortality.de_CH
dc.language.isoende_CH
dc.publisherNature Publishing Group de_CH
dc.relation.ispartofScientific Reportsde_CH
dc.rightshttp://creativecommons.org/licenses/by/4.0/de_CH
dc.subjectAgedde_CH
dc.subjectDeliriumde_CH
dc.subjectFemalede_CH
dc.subjectHospital mortalityde_CH
dc.subjectHumande_CH
dc.subjectLength of stayde_CH
dc.subjectLongitudinal studyde_CH
dc.subjectMalede_CH
dc.subjectMiddle agedde_CH
dc.subjectNeoplasmde_CH
dc.subjectRetrospective studyde_CH
dc.subjectInpatientde_CH
dc.subjectIntensive care unitde_CH
dc.subject.ddc616.8: Neurologie und Krankheiten des Nervensystemsde_CH
dc.titleOutcome, demography and resource utilization in ICU patients with delirium and malignancyde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementGesundheitde_CH
zhaw.organisationalunitInstitut für Pflege (IPF)de_CH
dc.identifier.doi10.1038/s41598-021-98200-8de_CH
dc.identifier.doi10.21256/zhaw-24022-
dc.identifier.pmid34548568de_CH
zhaw.funding.euNode_CH
zhaw.issue18756de_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume11de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Sieber, M., Rudiger, A., Schüpbach, R., Krüger, B., Schubert, M., & Bettex, D. (2021). Outcome, demography and resource utilization in ICU patients with delirium and malignancy. Scientific Reports, 11(18756). https://doi.org/10.1038/s41598-021-98200-8
Sieber, M. et al. (2021) ‘Outcome, demography and resource utilization in ICU patients with delirium and malignancy’, Scientific Reports, 11(18756). Available at: https://doi.org/10.1038/s41598-021-98200-8.
M. Sieber, A. Rudiger, R. Schüpbach, B. Krüger, M. Schubert, and D. Bettex, “Outcome, demography and resource utilization in ICU patients with delirium and malignancy,” Scientific Reports, vol. 11, no. 18756, 2021, doi: 10.1038/s41598-021-98200-8.
SIEBER, Mattia, Alain RUDIGER, Reto SCHÜPBACH, Bernard KRÜGER, Maria SCHUBERT und Dominique BETTEX, 2021. Outcome, demography and resource utilization in ICU patients with delirium and malignancy. Scientific Reports. 2021. Bd. 11, Nr. 18756. DOI 10.1038/s41598-021-98200-8
Sieber, Mattia, Alain Rudiger, Reto Schüpbach, Bernard Krüger, Maria Schubert, and Dominique Bettex. 2021. “Outcome, Demography and Resource Utilization in ICU Patients with Delirium and Malignancy.” Scientific Reports 11 (18756). https://doi.org/10.1038/s41598-021-98200-8.
Sieber, Mattia, et al. “Outcome, Demography and Resource Utilization in ICU Patients with Delirium and Malignancy.” Scientific Reports, vol. 11, no. 18756, 2021, https://doi.org/10.1038/s41598-021-98200-8.


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