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dc.contributor.authorNatsch, Andreas-
dc.contributor.authorEmter, Roger-
dc.contributor.authorBadertscher, Remo P.-
dc.contributor.authorBrunner, Gerhard-
dc.contributor.authorGranier, Thierry-
dc.contributor.authorKern, Susanne-
dc.contributor.authorEllis, Graham-
dc.date.accessioned2022-01-21T16:20:21Z-
dc.date.available2022-01-21T16:20:21Z-
dc.date.issued2015-06-15-
dc.identifier.issn0893-228Xde_CH
dc.identifier.issn1520-5010de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/23984-
dc.description.abstractHydroperoxides can act as specific haptens and oxidatively modify proteins. Terpene hydroperoxides trigger unusually high frequencies of positive skin reactions in human patients if tested at high concentrations. It is unknown whether this is due to specific hapten formation. Here, we show that both terpene hydroperoxides and the endogenous hydroperoxide formed from squalene can oxidatively modify tryptophan. Oxidative modifications of Trp were recently postulated to explain cross-sensitization between unrelated photosensitizers. Current observations may extend this hypothesis: Oxidative events triggered by endogenous hydroperoxides and hydroperoxides/oxidants derived from xenobiotics might lead to a sensitized state detected by patch tests with high concentrations of hydroperoxides.de_CH
dc.language.isoende_CH
dc.publisherAmerican Chemical Societyde_CH
dc.relation.ispartofChemical Research in Toxicologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectHydrogen peroxidede_CH
dc.subjectMolecular structurede_CH
dc.subjectOxidation-reductionde_CH
dc.subjectTryptophande_CH
dc.subjectDiagnostic test, routinede_CH
dc.subject.ddc540: Chemiede_CH
dc.titleOxidative tryptophan modification by terpene- and squalene-hydroperoxides and a possible link to cross-reactions in diagnostic testsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1021/acs.chemrestox.5b00039de_CH
dc.identifier.pmid25942677de_CH
zhaw.funding.euNode_CH
zhaw.issue6de_CH
zhaw.originated.zhawNode_CH
zhaw.pages.end1208de_CH
zhaw.pages.start1205de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume28de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Natsch, A., Emter, R., Badertscher, R. P., Brunner, G., Granier, T., Kern, S., & Ellis, G. (2015). Oxidative tryptophan modification by terpene- and squalene-hydroperoxides and a possible link to cross-reactions in diagnostic tests. Chemical Research in Toxicology, 28(6), 1205–1208. https://doi.org/10.1021/acs.chemrestox.5b00039
Natsch, A. et al. (2015) ‘Oxidative tryptophan modification by terpene- and squalene-hydroperoxides and a possible link to cross-reactions in diagnostic tests’, Chemical Research in Toxicology, 28(6), pp. 1205–1208. Available at: https://doi.org/10.1021/acs.chemrestox.5b00039.
A. Natsch et al., “Oxidative tryptophan modification by terpene- and squalene-hydroperoxides and a possible link to cross-reactions in diagnostic tests,” Chemical Research in Toxicology, vol. 28, no. 6, pp. 1205–1208, Jun. 2015, doi: 10.1021/acs.chemrestox.5b00039.
NATSCH, Andreas, Roger EMTER, Remo P. BADERTSCHER, Gerhard BRUNNER, Thierry GRANIER, Susanne KERN und Graham ELLIS, 2015. Oxidative tryptophan modification by terpene- and squalene-hydroperoxides and a possible link to cross-reactions in diagnostic tests. Chemical Research in Toxicology. 15 Juni 2015. Bd. 28, Nr. 6, S. 1205–1208. DOI 10.1021/acs.chemrestox.5b00039
Natsch, Andreas, Roger Emter, Remo P. Badertscher, Gerhard Brunner, Thierry Granier, Susanne Kern, and Graham Ellis. 2015. “Oxidative Tryptophan Modification by Terpene- and Squalene-Hydroperoxides and a Possible Link to Cross-Reactions in Diagnostic Tests.” Chemical Research in Toxicology 28 (6): 1205–8. https://doi.org/10.1021/acs.chemrestox.5b00039.
Natsch, Andreas, et al. “Oxidative Tryptophan Modification by Terpene- and Squalene-Hydroperoxides and a Possible Link to Cross-Reactions in Diagnostic Tests.” Chemical Research in Toxicology, vol. 28, no. 6, June 2015, pp. 1205–8, https://doi.org/10.1021/acs.chemrestox.5b00039.


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