| Publikationstyp: | Beitrag in wissenschaftlicher Zeitschrift |
| Art der Begutachtung: | Peer review (Publikation) |
| Titel: | Frequency, reactivity and evolution of human leukocyte antigen and human platelet antigen antibodies in the setting of hematopoietic cell transplantation |
| Autor/-in: | Bräutigam, Michelle Volken, Thomas Plattner, Alexandra Passweg, Jakob R. Halter, Jörg P. Drexler, Beatrice Heim, Dominik Schaub, Stefan Buser, Andreas S. Infanti, Laura Holbro, Andreas |
| et. al: | No |
| DOI: | 10.1016/j.transci.2021.103301 |
| Erschienen in: | Transfusion and Apheresis Science |
| Band(Heft): | 61 |
| Heft: | 2 |
| Seite(n): | 103301 |
| Erscheinungsdatum: | 29-Okt-2021 |
| Verlag / Hrsg. Institution: | Elsevier |
| ISSN: | 1473-0502 |
| Sprache: | Englisch |
| Schlagwörter: | HLA antibody; HPA antibody; Hematopoietic cell transplantation; Matched related; Donor derived |
| Fachgebiet (DDC): | 617: Chirurgie |
| Zusammenfassung: | Background and objectives: Antibodies (Ab) against HLA and HPA antigens play an important role in HCT. In this prospective study we evaluated prevalence and kinetics of HLA- and HPA-Ab after HCT, including a possible donor-recipient transfer and their clinical relevance in respect to platelet transfusion refractoriness (PTR). Materials and methods: Patients were consecutively recruited. Ab were determined by microbead assay technique and a mean fluorescence intensity cut-off of 1,000. Results: At baseline, 21 donors (42%) and 27 patients (54%) had HLA-Ab with a mean panel reactivity (cPRA) of 34.9 ± 29.4% and 46.1 ± 36.5%, respectively. We observed a significant higher number of HLA-Ab specificities in female donors and patients and a predominance of HLA-class I Ab. At day 0 we detected an increase of HLA-Ab (from 526 to 673) and cPRA (55.2 ± 31.9%). Thirty-six patients (72%) developed new HLA-Ab, mainly 3 weeks after HCT. In 7 patients an HLA-Ab with the same specificity as detected in the corresponding donor emerged, suggesting a possible transfer from the donor to the recipient. Overall, MFI showed a high variation. Type and number of transfusions were not associated with number and intensity of HLA-Ab (ρ: -0.05 – 0.02). Number of HLA-Ab, cPRA and intensity were not associated with PTR, which occurred in 9 patients (18%) and none had bleeding WHO > 2. Conclusions: Although a considerable number of patients have and develop HLA-Ab before and early after HCT, we found no association with PTR and bleeding and management should be individualized. |
| URI: | https://digitalcollection.zhaw.ch/handle/11475/23442 |
| Volltext Version: | Publizierte Version |
| Lizenz (gemäss Verlagsvertrag): | Lizenz gemäss Verlagsvertrag |
| Departement: | Gesundheit |
| Organisationseinheit: | Institut für Public Health (IPH) |
| Enthalten in den Sammlungen: | Publikationen Gesundheit |
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Bräutigam, M., Volken, T., Plattner, A., Passweg, J. R., Halter, J. P., Drexler, B., Heim, D., Schaub, S., Buser, A. S., Infanti, L., & Holbro, A. (2021). Frequency, reactivity and evolution of human leukocyte antigen and human platelet antigen antibodies in the setting of hematopoietic cell transplantation. Transfusion and Apheresis Science, 61(2), 103301. https://doi.org/10.1016/j.transci.2021.103301
Bräutigam, M. et al. (2021) ‘Frequency, reactivity and evolution of human leukocyte antigen and human platelet antigen antibodies in the setting of hematopoietic cell transplantation’, Transfusion and Apheresis Science, 61(2), p. 103301. Available at: https://doi.org/10.1016/j.transci.2021.103301.
M. Bräutigam et al., “Frequency, reactivity and evolution of human leukocyte antigen and human platelet antigen antibodies in the setting of hematopoietic cell transplantation,” Transfusion and Apheresis Science, vol. 61, no. 2, p. 103301, Oct. 2021, doi: 10.1016/j.transci.2021.103301.
BRÄUTIGAM, Michelle, Thomas VOLKEN, Alexandra PLATTNER, Jakob R. PASSWEG, Jörg P. HALTER, Beatrice DREXLER, Dominik HEIM, Stefan SCHAUB, Andreas S. BUSER, Laura INFANTI und Andreas HOLBRO, 2021. Frequency, reactivity and evolution of human leukocyte antigen and human platelet antigen antibodies in the setting of hematopoietic cell transplantation. Transfusion and Apheresis Science. 29 Oktober 2021. Bd. 61, Nr. 2, S. 103301. DOI 10.1016/j.transci.2021.103301
Bräutigam, Michelle, Thomas Volken, Alexandra Plattner, Jakob R. Passweg, Jörg P. Halter, Beatrice Drexler, Dominik Heim, et al. 2021. “Frequency, Reactivity and Evolution of Human Leukocyte Antigen and Human Platelet Antigen Antibodies in the Setting of Hematopoietic Cell Transplantation.” Transfusion and Apheresis Science 61 (2): 103301. https://doi.org/10.1016/j.transci.2021.103301.
Bräutigam, Michelle, et al. “Frequency, Reactivity and Evolution of Human Leukocyte Antigen and Human Platelet Antigen Antibodies in the Setting of Hematopoietic Cell Transplantation.” Transfusion and Apheresis Science, vol. 61, no. 2, Oct. 2021, p. 103301, https://doi.org/10.1016/j.transci.2021.103301.
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