Transfusions in aplastic anemia patients cause HLA alloimmunization Comparisons of current and past cohorts demonstrate progress

Julen, Katja; Volken, Thomas; Holbro, Andreas; Infanti, Laura; Halter, Jörg P.; Schaub, Stefan; Wehmeier, Caroline; Diesch, Tamara; Rovó, Alicia; Passweg, Jakob R; Buser, Andreas; Drexler, Beatrice

doi:10.1016/j.jtct.2021.07.017

Please use this identifier to cite or link to this item: https://doi.org/10.21256/zhaw-22980

Publication type:	Article in scientific journal
Type of review:	Peer review (publication)
Title:	Transfusions in aplastic anemia patients cause HLA alloimmunization Comparisons of current and past cohorts demonstrate progress
Authors:	Julen, Katja Volken, Thomas Holbro, Andreas Infanti, Laura Halter, Jörg P. Schaub, Stefan Wehmeier, Caroline Diesch, Tamara Rovó, Alicia Passweg, Jakob R Buser, Andreas Drexler, Beatrice
et. al:	No
DOI:	10.1016/j.jtct.2021.07.017 10.21256/zhaw-22980
Published in:	Transplantation and Cellular Therapy
Volume(Issue):	27
Issue:	11
Page(s):	939.e1
Pages to:	939.e8
Issue Date:	24-Jul-2021
Publisher / Ed. Institution:	Elsevier
ISSN:	2666-6367
Language:	English
Subjects:	HLA alloimmunization; HLA antibodies; Aplastic anemia
Subject (DDC):	616: Internal medicine and diseases
Abstract:	Background: Transfusions are the mainstay of supportive therapy in patients with aplastic anemia (AA) and may lead to anti-human leukocyte antigen (HLA) alloimmunization, thereby also increasing the risk for donor-specific antibodies in the setting of HLA-mismatched transplantation. Historically, AA patients were thought to be at particularly high risk for HLA alloimmunization. Objective: In the past decades, blood product manufacturing (leukoreduction), but also HLA antibody testing has improved significantly by single antigen bead (SAB) technology. It is currently unknown how those developments have impacted HLA-alloimmunization and treatment outcome in patients with AA. Study design: We retrospectively investigated 54 AA patients treated by immunosuppressive therapy and/or allogeneic hematopoietic cell transplantation after the introduction of the SAB assay at our center. We compared the HLA antibody results to a historical AA cohort (n=26), treated prior to introduction of leukoreduced blood products from 1975 to 1995. Results: HLA alloimmunization was detected in 43 of 54 (80%) patients in recently treated patient. Past pregnancy, female gender, disease severity, age and a history of more transfusions were significantly associated with a larger number and/or higher intensity (mean fluorescence intensity) of HLA antibodies. Treatment outcome including bleeding episodes, response to treatment, engraftment, GvHD and overall survival was not associated with HLA alloimmunization. In the historical cohort a significantly higher number of HLA antibodies (p<0.01) with a higher MFI (p<0.01) was observed. Conclusion: HLA alloimmunization remains frequent in AA tested by current techniques but it has significantly decreased since prior decades and does not affect treatment outcome.
URI:	https://digitalcollection.zhaw.ch/handle/11475/22980
Fulltext version:	Published version
License (according to publishing contract):	CC BY-NC-ND 4.0: Attribution - Non commercial - No derivatives 4.0 International
Departement:	School of Health Sciences
Organisational Unit:	Institute of Public Health (IPH)
Appears in collections:	Publikationen Gesundheit

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Julen, K., Volken, T., Holbro, A., Infanti, L., Halter, J. P., Schaub, S., Wehmeier, C., Diesch, T., Rovó, A., Passweg, J. R., Buser, A., & Drexler, B. (2021). Transfusions in aplastic anemia patients cause HLA alloimmunization Comparisons of current and past cohorts demonstrate progress. Transplantation and Cellular Therapy, 27(11), 939. https://doi.org/10.1016/j.jtct.2021.07.017

Julen, K. et al. (2021) ‘Transfusions in aplastic anemia patients cause HLA alloimmunization Comparisons of current and past cohorts demonstrate progress’, Transplantation and Cellular Therapy, 27(11), p. 939.e1–939.e8. Available at: https://doi.org/10.1016/j.jtct.2021.07.017.

K. Julen et al., “Transfusions in aplastic anemia patients cause HLA alloimmunization Comparisons of current and past cohorts demonstrate progress,” Transplantation and Cellular Therapy, vol. 27, no. 11, p. 939.e1–939.e8, Jul. 2021, doi: 10.1016/j.jtct.2021.07.017.

JULEN, Katja, Thomas VOLKEN, Andreas HOLBRO, Laura INFANTI, Jörg P. HALTER, Stefan SCHAUB, Caroline WEHMEIER, Tamara DIESCH, Alicia ROVÓ, Jakob R PASSWEG, Andreas BUSER und Beatrice DREXLER, 2021. Transfusions in aplastic anemia patients cause HLA alloimmunization Comparisons of current and past cohorts demonstrate progress. Transplantation and Cellular Therapy. 24 Juli 2021. Bd. 27, Nr. 11, S. 939.e1–939.e8. DOI 10.1016/j.jtct.2021.07.017

Julen, Katja, Thomas Volken, Andreas Holbro, Laura Infanti, Jörg P. Halter, Stefan Schaub, Caroline Wehmeier, et al. 2021. “Transfusions in Aplastic Anemia Patients Cause HLA Alloimmunization Comparisons of Current and Past Cohorts Demonstrate Progress.” Transplantation and Cellular Therapy 27 (11): 939. https://doi.org/10.1016/j.jtct.2021.07.017.

Julen, Katja, et al. “Transfusions in Aplastic Anemia Patients Cause HLA Alloimmunization Comparisons of Current and Past Cohorts Demonstrate Progress.” Transplantation and Cellular Therapy, vol. 27, no. 11, July 2021, p. 939, https://doi.org/10.1016/j.jtct.2021.07.017.