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|Publication type:||Article in scientific journal|
|Type of review:||Peer review (publication)|
|Title:||Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation|
Meyer, Andrea H.
Hellhammer, Dirk H.
|Published in:||Social Cognitive and Affective Neuroscience|
|Publisher / Ed. Institution:||Oxford University Press|
|Subjects:||Early life stress; Epigenetics; Intrauterine exposures delayed effect; Intrauterine programming; Psychosocial stress during pregnancy; Adult; Cross-sectional study; Depression; Female; Fetal blood; Human; Hydrocortisone; Infant; Life change event; Maternal behavior; Oxytocin; Pregnancy; Pregnancy trimester, third; Prenatal exposure delayed effect; Psychiatric status rating scale; Receptor, oxytocin; Stress, psychological; DNA methylation|
|Subject (DDC):||572: Biochemistry |
610: Medicine and health
|Abstract:||The aim of this study was to investigate whether maternal adversities and cortisol levels during pregnancy predict cord blood DNA methylation of the oxytocin receptor (OXTR). We collected cord blood of 39 babies born to mothers participating in a cross-sectional study (N = 100) conducted in Basel, Switzerland (2007-10). Mothers completed the Inventory of Life Events (second trimester: T2), the Edinburgh Postnatal Depression Scale (EPDS, third trimester: T3), the Trier Inventory of Chronic Stress (TICS-K, 1-3 weeks postpartum) and provided saliva samples (T2, T3) for maternal cortisol profiles, as computed by the area under the curve with respect to ground (AUCg) or increase (AUCi) for the cortisol awakening response (CAR) and for diurnal cortisol profiles (DAY). OXTR DNA methylation was quantified using Sequenom EpiTYPER. The number of stressful life events (P = 0.032), EPDS score (P = 0.007) and cortisol AUCgs at T2 (CAR: P = 0.020; DAY: P = 0.024) were negatively associated with OXTR DNA methylation. Our findings suggest that distinct prenatal adversities predict decreased DNA methylation in a gene that is relevant for childbirth, maternal behavior and wellbeing of mother and offspring. If a reduced OXTR methylation increases OXTR expression, our findings could suggest an epigenetic adaptation to an adverse early environment.|
|Further description:||Erworben im Rahmen der Schweizer Nationallizenzen (http://www.nationallizenzen.ch)|
|Fulltext version:||Published version|
|License (according to publishing contract):||Licence according to publishing contract|
|Departement:||School of Health Sciences|
|Organisational Unit:||Institute of Physiotherapy (IPT)|
|Appears in collections:||Publikationen Gesundheit|
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Unternaehrer, E., Bolten, M., Nast, I., Staehli, S., Meyer, A. H., Dempster, E., Hellhammer, D. H., Lieb, R., & Meinlschmidt, G. (2016). Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation. Social Cognitive and Affective Neuroscience, 11(9), 1460–1470. https://doi.org/10.1093/scan/nsw051
Unternaehrer, E. et al. (2016) ‘Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation’, Social Cognitive and Affective Neuroscience, 11(9), pp. 1460–1470. Available at: https://doi.org/10.1093/scan/nsw051.
E. Unternaehrer et al., “Maternal adversities during pregnancy and cord blood oxytocin receptor (OXTR) DNA methylation,” Social Cognitive and Affective Neuroscience, vol. 11, no. 9, pp. 1460–1470, 2016, doi: 10.1093/scan/nsw051.
Unternaehrer, Eva, et al. “Maternal Adversities during Pregnancy and Cord Blood Oxytocin Receptor (OXTR) DNA Methylation.” Social Cognitive and Affective Neuroscience, vol. 11, no. 9, 2016, pp. 1460–70, https://doi.org/10.1093/scan/nsw051.
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