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dc.contributor.authorLöffelholz, Christian-
dc.contributor.authorKaiser, Stephan C.-
dc.contributor.authorKraume, Matthias-
dc.contributor.authorEibl, Dieter-
dc.contributor.authorEibl-Schindler, Regine-
dc.date.accessioned2018-01-30T12:39:58Z-
dc.date.available2018-01-30T12:39:58Z-
dc.date.issued2014-
dc.identifier.isbn978-3-642-45157-7de_CH
dc.identifier.isbn978-3-642-45158-4de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/2263-
dc.description.abstractDuring the past 10 years, single-use bioreactors have been well accepted in modern biopharmaceutical production processes targeting high-value products. Up to now, such processes have mainly been small- or medium-scale mammalian cell culture-based seed inoculum, vaccine or antibody productions. However, recently first attempts have been made to modify existing single-use bioreactors for the cultivation of plant cells and tissue cultures, and microorganisms. This has even led to the development of new single-use bioreactor types. Moreover, due to safety issues it has become clear that single-use bioreactors are the “must have” for expanding human stem cells delivering cell therapeutics, the biopharmaceuticals of the next generation. So it comes as no surprise that numerous different dynamic single-use bioreactor types, which are suitable for a wide range of applications, already dominate the market today. Bioreactor working principles, main applications, and bioengineering data are presented in this review, based on a current overview of greater than milliliter-scale, commercially available, dynamic single-use bioreactors. The focus is on stirred versions, which are omnipresent in R&D and manufacturing, and in particular Sartorius Stedim’s BIOSTAT family. Finally, we examine development trends for single-use bioreactors, after discussing proven approaches for fast scaling-up processes.de_CH
dc.language.isoende_CH
dc.publisherSpringerde_CH
dc.relation.ispartofDisposable bioreactors IIde_CH
dc.relation.ispartofseriesAdvances in Biochemical Engineering/Biotechnologyde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectComputational fluid dynamicsde_CH
dc.subjectEngineering characteristicsde_CH
dc.subjectMain applicationsde_CH
dc.subjectScale-upde_CH
dc.subjectSingle-use bioreactor typesde_CH
dc.subject.ddc660: Technische Chemiede_CH
dc.titleDynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling upde_CH
dc.typeBuchbeitragde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
zhaw.publisher.placeBerlinde_CH
dc.identifier.doi10.1007/10_2013_187de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end41de_CH
zhaw.pages.start1de_CH
zhaw.parentwork.editorEibl, Dieter-
zhaw.parentwork.editorEibl-Schindler, Regine-
zhaw.publication.statuspublishedVersionde_CH
zhaw.series.number138de_CH
zhaw.publication.reviewEditorial reviewde_CH
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Löffelholz, C., Kaiser, S. C., Kraume, M., Eibl, D., & Eibl-Schindler, R. (2014). Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up. In D. Eibl & R. Eibl-Schindler (Eds.), Disposable bioreactors II (pp. 1–41). Springer. https://doi.org/10.1007/10_2013_187
Löffelholz, C. et al. (2014) ‘Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up’, in D. Eibl and R. Eibl-Schindler (eds) Disposable bioreactors II. Berlin: Springer, pp. 1–41. Available at: https://doi.org/10.1007/10_2013_187.
C. Löffelholz, S. C. Kaiser, M. Kraume, D. Eibl, and R. Eibl-Schindler, “Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up,” in Disposable bioreactors II, D. Eibl and R. Eibl-Schindler, Eds. Berlin: Springer, 2014, pp. 1–41. doi: 10.1007/10_2013_187.
LÖFFELHOLZ, Christian, Stephan C. KAISER, Matthias KRAUME, Dieter EIBL und Regine EIBL-SCHINDLER, 2014. Dynamic single-use bioreactors used in modern liter- and m3-scale biotechnological processes : engineering characteristics and scaling up. In: Dieter EIBL und Regine EIBL-SCHINDLER (Hrsg.), Disposable bioreactors II. Berlin: Springer. S. 1–41. ISBN 978-3-642-45157-7
Löffelholz, Christian, Stephan C. Kaiser, Matthias Kraume, Dieter Eibl, and Regine Eibl-Schindler. 2014. “Dynamic Single-Use Bioreactors Used in Modern Liter- and M3-Scale Biotechnological Processes : Engineering Characteristics and Scaling Up.” In Disposable Bioreactors II, edited by Dieter Eibl and Regine Eibl-Schindler, 1–41. Berlin: Springer. https://doi.org/10.1007/10_2013_187.
Löffelholz, Christian, et al. “Dynamic Single-Use Bioreactors Used in Modern Liter- and M3-Scale Biotechnological Processes : Engineering Characteristics and Scaling Up.” Disposable Bioreactors II, edited by Dieter Eibl and Regine Eibl-Schindler, Springer, 2014, pp. 1–41, https://doi.org/10.1007/10_2013_187.


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