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  2. Angewandte Psychologie
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  4. Publikationen Angewandte Psychologie
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dc.contributor.authorHengartner, Michael Pascal-
dc.contributor.authorAmendola, Simone-
dc.contributor.authorKaminski, Jakob A.-
dc.contributor.authorKindler, Simone-
dc.contributor.authorBschor, Tom-
dc.contributor.authorPlöderl, Martin-
dc.date.accessioned2021-03-26T15:37:00Z-
dc.date.available2021-03-26T15:37:00Z-
dc.date.issued2021-
dc.identifier.issn0143-005Xde_CH
dc.identifier.issn1470-2738de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/22198-
dc.description.abstractBackground: There is ongoing controversy whether antidepressant use alters suicide risk in adults with depression and other treatment indications. Methods: Systematic review of observational studies, searching MEDLINE, PsycINFO, Web of Science, PsycARTICLES and SCOPUS for case–control and cohort studies. We included studies on depression and various indications unspecified (including off-label use) reporting risk of suicide and/or suicide attempt for adult patients using selective serotonin reuptake inhibitors (SSRI) and other new-generation antidepressants relative to non-users. Effects were meta-analytically aggregated with random-effects models, reporting relative risk (RR) estimates with 95% CIs. Publication bias was assessed via funnel-plot asymmetry and trim-and-fill method. Financial conflict of interest (fCOI) was defined present when lead authors’ professorship was industry-sponsored, they received industry-payments, or when the study was industry-sponsored. Results: We included 27 studies, 19 on depression and 8 on various indications unspecified (n=1.45 million subjects). SSRI were not definitely related to suicide risk (suicide and suicide attempt combined) in depression (RR=1.03, 0.70–1.51) and all indications (RR=1.19, 0.88–1.60). Any new-generation antidepressant was associated with higher suicide risk in depression (RR=1.29, 1.06–1.57) and all indications (RR=1.45, 1.2–1.70). Studies with fCOI reported significantly lower risk estimates than studies without fCOI. Funnel-plots were asymmetrical and imputation of missing studies with trim-and-fill method produced considerably higher risk estimates. Conclusions: Exposure to new-generation antidepressants is associated with higher suicide risk in adult routine-care patients with depression and other treatment indications. Publication bias and fCOI likely contribute to systematic underestimation of risk in the published literature.de_CH
dc.language.isoende_CH
dc.publisherBMJ Publishing Groupde_CH
dc.relation.ispartofJournal of Epidemiology & Community Healthde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectDepressionde_CH
dc.subjectEpidemiologyde_CH
dc.subjectPublic healthde_CH
dc.subjectSuicidede_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleSuicide risk with selective serotonin reuptake inhibitors and other new-generation antidepressants in adults: a systematic review and meta-analysis of observational studiesde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementAngewandte Psychologiede_CH
zhaw.organisationalunitPsychologisches Institut (PI)de_CH
dc.identifier.doi10.1136/jech-2020-214611de_CH
dc.identifier.pmid33685964de_CH
zhaw.funding.euNode_CH
zhaw.originated.zhawYesde_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.webfeedKlinische Psychologiede_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
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Hengartner, M. P., Amendola, S., Kaminski, J. A., Kindler, S., Bschor, T., & Plöderl, M. (2021). Suicide risk with selective serotonin reuptake inhibitors and other new-generation antidepressants in adults: a systematic review and meta-analysis of observational studies. Journal of Epidemiology & Community Health. https://doi.org/10.1136/jech-2020-214611
Hengartner, M.P. et al. (2021) ‘Suicide risk with selective serotonin reuptake inhibitors and other new-generation antidepressants in adults: a systematic review and meta-analysis of observational studies’, Journal of Epidemiology & Community Health [Preprint]. Available at: https://doi.org/10.1136/jech-2020-214611.
M. P. Hengartner, S. Amendola, J. A. Kaminski, S. Kindler, T. Bschor, and M. Plöderl, “Suicide risk with selective serotonin reuptake inhibitors and other new-generation antidepressants in adults: a systematic review and meta-analysis of observational studies,” Journal of Epidemiology & Community Health, 2021, doi: 10.1136/jech-2020-214611.
HENGARTNER, Michael Pascal, Simone AMENDOLA, Jakob A. KAMINSKI, Simone KINDLER, Tom BSCHOR und Martin PLÖDERL, 2021. Suicide risk with selective serotonin reuptake inhibitors and other new-generation antidepressants in adults: a systematic review and meta-analysis of observational studies. Journal of Epidemiology & Community Health. 2021. DOI 10.1136/jech-2020-214611
Hengartner, Michael Pascal, Simone Amendola, Jakob A. Kaminski, Simone Kindler, Tom Bschor, and Martin Plöderl. 2021. “Suicide Risk with Selective Serotonin Reuptake Inhibitors and Other New-Generation Antidepressants in Adults: A Systematic Review and Meta-Analysis of Observational Studies.” Journal of Epidemiology & Community Health. https://doi.org/10.1136/jech-2020-214611.
Hengartner, Michael Pascal, et al. “Suicide Risk with Selective Serotonin Reuptake Inhibitors and Other New-Generation Antidepressants in Adults: A Systematic Review and Meta-Analysis of Observational Studies.” Journal of Epidemiology & Community Health, 2021, https://doi.org/10.1136/jech-2020-214611.


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