Publication type: Article in scientific journal
Type of review: Peer review (publication)
Title: Challenges with matrix metalloproteinase inhibition and future drug discovery avenues
Authors: Fischer, Thomas
Riedl, Rainer
et. al: No
DOI: 10.1080/17460441.2020.1819235
Published in: Expert Opinion on Drug Discovery
Volume(Issue): 16
Issue: 1
Pages: 75
Pages to: 88
Issue Date: 14-Sep-2020
Publisher / Ed. Institution: Taylor & Francis
ISSN: 1746-0441
Language: English
Subjects: Antibodies; Drug design; Drug discovery; Hemopexin-like domain; Matrix metalloproteinase; Medicinal chemistry; Polypharmacology; Small-molecule inhibitors
Subject (DDC): 615: Pharmacology and therapeutics
Abstract: Matrix metalloproteinases have been in the scope of pharmaceutical drug discovery for decades as promising targets for drug development. Until present, no modulator of the enzyme class survived clinical trials, all failing for various reasons. Nevertheless, the target family did not lose its attractiveness and there is ever more evidence that MMP modulators are likely to overcome the hurdles and result in successful clinical therapies.
Fulltext version: Published version
License (according to publishing contract): Licence according to publishing contract
Departement: Life Sciences and Facility Management
Organisational Unit: Institute of Chemistry and Biotechnology (ICBT)
Appears in collections:Publikationen Life Sciences und Facility Management

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