Full metadata record
DC FieldValueLanguage
dc.contributor.authorFischer, Thomas-
dc.contributor.authorSenn, Nicole-
dc.contributor.authorRiedl, Rainer-
dc.date.accessioned2021-02-18T10:42:22Z-
dc.date.available2021-02-18T10:42:22Z-
dc.date.issued2019-02-05-
dc.identifier.issn0947-6539de_CH
dc.identifier.issn1521-3765de_CH
dc.identifier.urihttps://digitalcollection.zhaw.ch/handle/11475/21750-
dc.description.abstractMatrix metalloproteinases (MMPs) are involved in a multitude of severe diseases. Despite MMPs being considered druggable targets, past drug-discovery programs have not delivered the anticipated clinical benefits. This review examines the latest structural evolution of small-molecule inhibitors of MMPs, with a focus on the development of novel chemical entities with improved affinity and selectivity profiles. X-ray crystallographic data of the protein targets and cocrystal structures with inhibitors proved to be key for the success achieved during this ambitious endeavor. An evolutionary view on the structural diversity generated for this class of molecules is provided. This encouraging development paves the way for the clinical utilization of this class of highly relevant therapeutic targets. The structure-based design of superior MMP inhibitors highlights the power of this technique and displays strategies for the development of treatment options based on the modulation of challenging drug targets.de_CH
dc.language.isoende_CH
dc.publisherWileyde_CH
dc.relation.ispartofChemistry – A European Journalde_CH
dc.rightsLicence according to publishing contractde_CH
dc.subjectDrug desginde_CH
dc.subjectDrug discoveryde_CH
dc.subjectInhibitorsde_CH
dc.subjectMedicinal chemistryde_CH
dc.subjectMetalloenzymede_CH
dc.subjectAnimalde_CH
dc.subjectHumande_CH
dc.subjectMatrix metalloproteinase inhibitorsde_CH
dc.subjectMatrix metalloproteinasesde_CH
dc.subjectMolecular modelde_CH
dc.subjectStructure-activity relationshipde_CH
dc.subject.ddc615: Pharmakologie und Therapeutikde_CH
dc.titleDesign and structural evolution of matrix metalloproteinase inhibitorsde_CH
dc.typeBeitrag in wissenschaftlicher Zeitschriftde_CH
dcterms.typeTextde_CH
zhaw.departementLife Sciences und Facility Managementde_CH
zhaw.organisationalunitInstitut für Chemie und Biotechnologie (ICBT)de_CH
dc.identifier.doi10.1002/chem.201805361de_CH
dc.identifier.pmid30720221de_CH
zhaw.funding.euNode_CH
zhaw.issue34de_CH
zhaw.originated.zhawYesde_CH
zhaw.pages.end7980de_CH
zhaw.pages.start7960de_CH
zhaw.publication.statuspublishedVersionde_CH
zhaw.volume25de_CH
zhaw.publication.reviewPeer review (Publikation)de_CH
zhaw.author.additionalNode_CH
zhaw.display.portraitYesde_CH
Appears in collections:Publikationen Life Sciences und Facility Management

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.